早期微量喂养可提高新生儿耐受并降低胆汁淤积

发布时间：2019-03-12 10:27

【摘要】：为了探讨早期微量喂养提高新生儿耐受和降低胆汁淤积的效果研究,选取2012年2月至2014年2月来我院进行抢救的出现急性呼吸衰竭患儿120例,按照随机数字表法将其分为A组和B组。给予A组患儿全静脉营养,给予B组患儿早期微量喂养,对比治疗期间两组患儿耐受情况和出现不良反应情况;记录两组患儿体重恢复所需时间、进行机械通气的总时间、患儿达到全量胃肠营养的总时间和住院时长;比较两组患儿出现胆汁淤积例数;对比干预前后患儿血清总胆红素、血清总胆汁酸和结合胆红素水平。研究显示,B组患儿耐受人数显著高于A组患儿(p0.05);B组患儿胃肠功能紊乱与坏死性小肠结肠炎数量明显低于A组患儿(p0.05);B组患儿达全量胃肠营养总时长和住院时长都明显短于A组患儿(p0.05)。B组患儿出现胆汁淤积例数显著少于A组患儿(p0.05)。治疗后B组患儿TBIL、DBIL、TBA水平均显著低于A组患儿(p0.05)。因此,对进行机械通气的新生儿采用早期微量喂养,有利于提高患儿治疗耐受性,减少并发症的发生,缩短患儿住院时长,值得临床推广。
[Abstract]:In order to investigate the effect of early micro-feeding on improving neonatal tolerance and reducing cholestasis, 120 children with acute respiratory failure were selected from February 2012 to February 2014 in our hospital. They were divided into group A and group B according to the random number table method. Children in group A were given total parenteral nutrition and children in group B were given early micro-feeding. The tolerance and adverse reactions were compared between the two groups during the treatment. The time of recovery of body weight, the total time of mechanical ventilation, the total time of reaching total gastrointestinal nutrition and the length of stay in hospital were recorded, and the number of cases of cholestasis was compared between the two groups. The levels of serum total bilirubin, serum total bile acid and binding bilirubin were compared before and after intervention. The results showed that the number of children with tolerance in group B was significantly higher than that in group A (p0.05); B group, the number of gastrointestinal dysfunction and necrotizing enterocolitis was significantly lower than that in group A (p0.05); The total duration of total parenteral nutrition and the length of hospitalization in group B were significantly shorter than those in group A (p0.05). B group had less cases of cholestasis than those in group A (p0.05). After treatment, the level of TBIL,DBIL,TBA in group B was significantly lower than that in group A (p0.05). Therefore, the use of early micro-feeding for newborn infants undergoing mechanical ventilation is beneficial to improve the treatment tolerance, reduce the occurrence of complications and shorten the length of stay in hospital, which is worthy of clinical popularization.
【作者单位】：湘南学院;湘南学院附属医院;
【基金】：郴州湘南学院资助
【分类号】：R722.1

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