患儿血管迷走性晕厥直立倾斜试验血浆C型钠尿肽变化及其意义

发布时间：2019-04-13 13:03

【摘要】：目的探讨血管迷走性晕厥(vasovagal syncope,VVS)患儿血浆C-型钠尿肽(c-type natriuretic peptide,CNP)含量的变化。方法研究对象包括31例VVS患儿,均为2013年12月至2014年6月在北京大学第一医院儿科以直立不耐受症状入院的患儿,均经过详细病史询问、体格检查及相关实验室检查以及直立倾斜试验(HUTT)确诊为VVS,平均年龄为(11±3)岁;32名健康儿童为对照组,均为经过详细病史及体格检查等确定为健康的儿童,平均年龄为(11±2)岁。心率、血压的监测采用无创连续血压监测仪连续监测。血浆CNP的测定采用夹心免疫发光法。结果 VVS组与对照组的性别比、年龄、身高、体重、平卧位血压及心率差异均无统计学意义(P0.05);VVS患儿血浆中CNP含量明显高于正常儿童[(35.7±21.5)ng/L vs.(23.2±8.0)ng/L,P0.01)];VVS患儿的晕厥频率与血浆中的CNP含量呈明显正相关(n=31,r=0.85,P0.01)。VVS组平卧状态下及HUTT中阳性反应时的血浆CNP含量差异无统计学意义[(36.3±21.0)ng/L vs.(42±57)ng/L,P0.05]。结论 VVS患儿血浆CNP含量高于对照组,且血浆CNP含量与患儿晕厥频率相关,可能参与了VVS的发病过程。
[Abstract]:Objective to investigate the changes of plasma C-type natriuretic peptide (c-type natriuretic peptide,CNP) in children with vasovagal syncope (vasovagal syncope,VVS). Methods from December 2013 to June 2014, 31 children with VVS were admitted to the Pediatrics Department of Pediatrics, Peking University first Hospital. The mean age of VVS, diagnosed by physical examination, related laboratory examination and vertical tilt test (HUTT) was (11 卤3) years. 32 healthy children (11 卤2 years old) were confirmed as healthy children by detailed medical history and physical examination, and the mean age was (11 卤2) years old. Heart rate and blood pressure were monitored continuously by non-invasive continuous blood pressure monitor. Plasma CNP was determined by sandwich immunoluminescence method. Results there was no significant difference in sex ratio, age, height, weight, blood pressure and heart rate between VVS group and control group (P0.05). The level of plasma CNP in children with VVS was significantly higher than that in normal children [(35.7 卤21.5) ng/L vs. (23.2 卤8.0) ng/L,P0.01]. There was a significant positive correlation between syncope frequency and plasma CNP level in children with VVS (n = 31, r = 0.85, P < 0.01). There was no significant difference in plasma CNP content between). VVS group and HUTT group [(36.3 卤21.0) ng/L vs., (42 卤57) ng/L,P0.05]. Conclusion the level of plasma CNP in children with VVS is higher than that in control group, and the content of plasma CNP is correlated with the frequency of syncope in children with VVS, which may be involved in the pathogenesis of VVS.
【作者单位】：北京大学第一医院儿科;开封市儿童医院;北京大学基础医学院生理学与病理生理学系;分子心血管学教育部重点实验室;
【分类号】：R725.4

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