依托咪酯用量对左向右分流先天性心脏病患儿血流动力学及脑电双频指数的影响

发布时间：2019-05-28 07:11

【摘要】：目的·分析左向右分流先天性心脏病患儿连续泵注依托咪酯镇静时剂量与脑电双频指数(BIS)的相关性。方法·24例左向右分流先天性心脏病患儿全身麻醉诱导后停止吸入七氟醚,使BIS值逐渐恢复至80;经外周静脉按0.3 mg/(kg·min)剂量持续泵注依托咪酯,待BIS值为40时停止泵入;记录期间BIS为80、70、60、50和40时心率(HR)、动脉压(ABP)和中心静脉压(CVP)的变化及依托咪酯总的用量,分析左向右分流先天性心脏病患儿连续泵注依托咪酯镇静时剂量与BIS的相关性。结果·依托咪酯持续泵注至BIS值达到40时,患儿血流动力学变化不明显,依托咪酯与BIS值呈负相关(r=-0.769,P0.01);2岁以下先天性心脏病患儿依托咪酯平均剂量高于2岁以上先天性心脏病患儿(P=0.034)。结论·依托咪酯对左向右分流先天性心脏病患儿血流动力学的影响较小,泵注剂量与BIS值呈负相关;左向右分流先天性心脏病患儿BIS与年龄可能有一定关系。
[Abstract]:Objective to analyze the correlation between the dose of etomidate sedation and EEG bispectral index (BIS) in children with left-to-right shunt congenital heart disease. Methods Twenty-four children with left-to-right shunt congenital heart disease stopped inhaling sevoflurane after general anesthesia induction, and the BIS value was gradually restored to 80. Etomidate was continuously injected into the peripheral vein at a dose of 0.3 mg/ (kg 路min), and stopped pumping when the BIS value was 40. During the recording period, the changes of heart rate (HR), arterial pressure (ABP) and central venous pressure (CVP) and the total dosage of etomidate were 80, 70, 60, 50 and 40, respectively. To analyze the correlation between the dose of etomidate and BIS in children with left to right shunt congenital heart disease. Results after continuous infusion of etomidate until the BIS value reached 40, the hemodynamic changes of the children were not obvious, but there was a negative correlation between etomidate and BIS value (r 鈮，

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