活血利胆退黄经验方对CMV感染相关胆汁淤积性肝炎患儿的辅助治疗效果观察

发布时间：2019-06-02 16:38

【摘要】：目的:研究分析活血利胆退黄经验方辅助常规西医疗法治疗巨细胞病毒(CMV)感染相关胆汁淤积性肝炎患儿的临床效果。方法:选取本院收治的123例CMV相关胆汁淤积性肝炎患儿,随机分为中西医组62例和西医组61例,两组均给予更昔洛韦抗病毒、保肝护肝、维生素、熊去氧胆酸等常规治疗,中西医组加用活血利胆退黄经验方进行辅助治疗,两组患儿的疗程均为5周,观察临床指标及治疗效果差异。结果:治疗后中西医组的TBIL、DBIL、TBA值均显著的低于西医组患儿(P0.05),中西医组的CVM-DNA转阴率59.68%显著的高于对照组52.46%(P0.05)。中西医组患儿的黄疸消退时间、肝脏回缩时间、脾脏回缩时间均显著的短于西医组患儿(P0.05)。治疗后中西医组的中医证候积分值显著的低于西医组患儿且差异具有统计学意义(P0.05)。治疗后中西医组患儿的总有效率(98.39%)高于西医组的(95.08%)但差异无统计学意义(P0.05)。结论:活血利胆退黄经验方辅助常规西医疗法治疗CMV感染相关胆汁淤积性肝炎能够尽快缓解患儿的临床症状、体征及指标恢复,是对西医疗法的重要补充。
[Abstract]:Objective: to study and analyze the clinical effect of Huoxue Lidan Tuihuang recipe combined with conventional western medicine in the treatment of children with cholestatic hepatitis associated with Cytomegalovirus (CMV) infection. Methods: 123 children with CMV-related cholestatic hepatitis were randomly divided into traditional Chinese and western medicine group (n = 62) and western medicine group (n = 61). Both groups were treated with ganciclovir antivirus, liver protection and liver protection, vitamins and ursodeoxycholic acid. In the traditional Chinese and western medicine group, Huoxue Lidan antipyretic prescription was used for auxiliary treatment. The course of treatment of the two groups was 5 weeks. The clinical indexes and therapeutic effect were observed. Results: after treatment, the TBIL,DBIL, TBA value in the traditional Chinese and western medicine group was significantly lower than that in the western medicine group (P 0.05). The negative conversion rate of CVM-DNA in the traditional Chinese and western medicine group was 59.68%, which was significantly higher than that in the control group (52.46%). The jaundice regression time, liver retraction time and spleen retraction time in the Chinese and western medicine group were significantly shorter than those in the western medicine group (P 0.05). After treatment, the score of TCM syndromes in the traditional Chinese and western medicine group was significantly lower than that in the western medicine group, and the difference was statistically significant (P 0.05). After treatment, the total effective rate of children in Chinese and western medicine group (98.39%) was higher than that in western medicine group (95.08%), but there was no significant difference (P 0.05). Conclusion: Huoxue Lidan Tuihuang prescription can relieve the clinical symptoms, signs and indexes of children with CMV infection related cholestasis hepatitis as soon as possible, which is an important supplement to western medicine therapy.
【作者单位】：武汉市妇女儿童医疗保健中心;黄石市妇幼保健院;
【分类号】：R725.1

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