389例手足口病例EV71和CA16型肠道病毒感染情况调查

发布时间：2019-07-09 08:26

【摘要】：目的调查389例儿童手足口病例肠道病毒(EV71)和柯萨奇病毒A组16型(CA16)感染情况,为手足口病的防控提供指导。方法以2016年河南省郑州儿童医院确诊的582例手足口病患儿为研究对象,收集患儿咽拭子、肛拭子和粪便标本,对EV71、CA16以及肠道病毒通用型(EV-G)进行特异性核酸检测,对手足口病患者的流行特征进行描述性分析。结果 582例手足口病病例中肠道病毒阳性389例,其中EV71感染119例,占30.59%,CA16感染83例,占21.34%;其他肠道病毒感染187例,占48.07%。春、夏、秋、冬四季手足口病病例数分别为154、79、65和91例,其中EV71感染致手足口病病例数分别为47、24、16和32例,CA16感染病例数分别为31、16、13和23例。6月龄患儿110例,EV71、CA16及其他肠道病毒致手足口病例数分别为31、16和63例;12月龄患儿201例,病例数分别为60、43和98例;2436月龄患儿78例,病例数分别为28、24和26例。男性患儿217例,占55.78%,女性患儿172例,占44.22%。幼托儿童、散居儿童及其他儿童肠道病毒感染病例数分别为297、59和33例,EV71感染分别为84、27和8例,CA16感染分别为53、19和11例,其他肠道病毒感染分别为160、13和14例。结论手足口病患儿感染肠道病毒类型以EV71型为主,春季为肠道病毒感染高峰期,1224月龄男童为高发人群;儿童聚集环境应及时通风消毒等,控制病毒传播。
[Abstract]:Objective to investigate the infection of enterovirus (EV71) and coxsackievirus group A 16 (CA16) in 389 children with hand, foot and mouth disease, and to provide guidance for the prevention and control of HFMD. Methods 582 children with HFMD diagnosed in Zhengzhou Children's Hospital of Henan Province in 2016 were studied. Pharynx swabs, anal swabs and feces were collected. EV71,CA16 and enterovirus universal type (EV-G) were detected by specific nucleic acid, and the epidemic characteristics of patients with hand, foot and mouth disease were analyzed. Results among 582 cases of HFMD, 389 cases were positive for enterovirus, including 119 cases (30.59%) with EV71 infection, 83 cases (21.34%) with CA16 infection, and 187 cases (48.07%) with other enterovirus infections. The number of cases of HFMD caused by EV71 infection was 47, 24, 16 and 32, respectively, and the number of cases of CA16 infection was 31, 16, 13 and 23, respectively. 110 cases of HFMD caused by EV71,CA16 and other enterovirus were 31 cases, 16 cases and 63 cases in 6 months old children, 6043 cases and 98 cases in 12 months old children, 78 cases in 2436 months old children, 31 cases in 6 months old children, 61 cases and 63 cases in EV71,CA16 and other enterovirus cases, 6043 cases and 98 cases in 12 months old children, and 78 cases in 2436 months old children. There were 217 male children (55.78%) and 172 female children (44.22%). The number of cases of enterovirus infection, EV71 infection, CA16 infection and other enterovirus infections in young children, diasporic children and other children were 29.7, 59 and 33, 84, 27 and 8, 53, 19 and 11, respectively, and those of other enterovirus infections were 160, 13 and 14, respectively. the number of enterovirus infections in young children, diasporic children and other children was 287, 59 and 33, 84, 27 and 8, 53, 19 and 11, respectively. Conclusion EV 71 is the main type of enterovirus infection in children with HFMD, the peak period of enterovirus infection is in spring, and boys of 1224 months old are the high incidence population, and the gathering environment of children should be ventilated and sterilized in time to control the transmission of the virus.
【作者单位】： 郑州儿童医院康复中心;河南省疾病预防控制中心;
【基金】：2015年河南省医学科技攻关计划项目(No.201402010)
【分类号】：R725.1
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本文编号：2512018