婴幼儿反复喘息的危险因素研究

发布时间：2019-08-17 19:37

【摘要】：目的探讨婴幼儿反复喘息的危险因素。方法选取2015年河北省儿童医院、河北医科大学第一医院、唐山市妇幼保健院收治的由支气管肺炎引起的反复喘息婴幼儿453例,其中API阳性患儿152例(API阳性组),API阴性患儿301例(API阴性组);选取同期、同年龄在以上3个医院住院的支气管肺炎患儿318例作为对照组。采用回顾性分析法,通过查阅病历收集患儿的临床资料,包括性别、早产、超重/肥胖、生活环境及母孕期吸烟、应用抗生素及非甾体抗炎药情况。危险因素分析采用多因素Logistic回归分析。结果 3组年龄、性别间差异无统计学意义(P0.05);而早产、超重/肥胖、生活环境及母孕期吸烟、应用抗生素及非甾体抗炎药间差异有统计学意义(P0.05)。多因素Logistic回归分析结果显示,早产、超重/肥胖、生活在城市及母孕期吸烟、应用抗生素及非甾体抗炎药是婴幼儿反复喘息的危险因素(P0.05)。结论患儿早产、超重或肥胖、生活在城市及母亲孕期吸烟、应用抗生素及非甾体抗炎药,是婴幼儿反复喘息的危险因素。
[Abstract]:Objective to explore the risk factors of recurrent wheezing in infants. Methods in 2015, 453 infants with recurrent wheezing caused by bronchopneumonia were treated in Hebei Children's Hospital, the first Hospital of Hebei Medical University and Tangshan Maternal and Child Health Hospital, including 152 children with API positive (API negative group) and 318 children with bronchopneumonia hospitalized in the above three hospitals at the same time as the control group. The clinical data of children, including sex, premature delivery, overweight / obesity, living environment and maternal smoking during pregnancy, antibiotics and non-steroidal anti-inflammatory drugs were collected by retrospective analysis. Multivariate Logistic regression analysis was used to analyze the risk factors. Results there was no significant difference in age and sex among the three groups (P 0.05), but there were significant differences in premature delivery, overweight / obesity, living environment and maternal smoking during pregnancy, antibiotics and non-steroidal anti-inflammatory drugs (P 0.05). Multivariate Logistic regression analysis showed that premature delivery, overweight / obesity, smoking in cities and pregnant women, and the use of antibiotics and non-steroidal anti-inflammatory drugs were the risk factors for recurrent wheezing in infants (P 0.05). Conclusion premature delivery, overweight or obesity, smoking in cities and mothers during pregnancy, and the use of antibiotics and non-steroidal anti-inflammatory drugs are the risk factors for recurrent wheezing in infants.
【作者单位】：河北省儿童医院呼吸三科;河北医科大学第一医院儿科;河北省唐山市妇幼保健院小儿呼吸科;
【基金】：河北省医学科学研究重点课题计划(20160429)
【分类号】：R725.6

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