慢性丘脑梗死患者全脑灰质体积改变及与认知功能减退的关系

发布时间：2018-01-13 11:48

本文关键词：慢性丘脑梗死患者全脑灰质体积改变及与认知功能减退的关系　出处：《中国医学影像技术》2016年05期 　论文类型：期刊论文

【摘要】：目的探讨慢性丘脑梗死患者全脑灰质体积改变及与认知功能减退的关系。方法对26例慢性丘脑梗死患者(梗死组)和29名健康志愿者(对照组)进行神经心理学评价及MR扫描。分别计算全脑灰质、白质、丘脑梗死体积,并进行统计学分析。结果与对照组比较,梗死组简易精神状态检查量表(MMSE)评分、短延迟回忆、长延迟回忆、再确认及图形回忆评分均明显降低(P均0.05);梗死组全脑灰质体积与对照组比较明显减小[梗死组:(774 291.49±42 370.85)mm~3,对照组(802 999.21±37 075.84)mm~3,t=2.442,P=0.018]。梗死组全脑白质体积与对照组比较,差异无统计学意义[(705 587.51±32 886.53)mm~3,(717 580.47±31 911.05)mm3,t=1.634,P=0.108]。梗死组全脑灰质体积与MMSE评分及图形回忆评分呈中度正相关(r=0.491、0.427,P=0.017、0.042);全脑灰质体积与短延迟回忆、长延迟回忆、再确认评分均无相关性(P均0.05);丘脑梗死体积与全脑灰质体积、MMSE评分、短延迟回忆、长延迟回忆、再确认及图形回忆评分均无相关性(P均0.05)。结论慢性丘脑梗死患者全脑灰质体积减小,可能是其认知功能减退的原因。
[Abstract]:Objective to investigate the changes of global gray matter volume in patients with chronic thalamic infarction and its relationship with cognitive impairment. Methods 26 patients with chronic thalamic infarction (infarction group) and 29 healthy volunteers (control group) were enrolled in this study. Neuropsychological evaluation and Mr scan were performed. The gray matter of the whole brain was calculated. Results compared with the control group, the infarct volume of white matter and thalamus was statistically analyzed. Results compared with the control group, the MMSE score, short delayed recall and long delayed recall were found in the infarct group. The scores of reconfirmation and pattern recall were significantly decreased (P < 0.05). Compared with the control group, the whole brain gray matter volume in the infarct group decreased significantly. [In the infarct group, 774 291.49 卤42 370.85 mm / min, and in the control group 802 999.21 卤37 075.84 mm / min respectively. There was no significant difference in white matter volume between the infarct group and the control group. [717 580.47 卤31 911.05 卤31 911.05 mm ~ (3) t ~ (1.634). The gray matter volume of the whole brain was positively correlated with the MMSE score and the pattern recall score in the infarcted group (P < 0. 491 / 0. 427, P < 0. 017 ~ 0. 042). The whole brain gray matter volume had no correlation with short delayed recall, long delayed recall and reconfirmation score (P < 0.05). The infarct volume of thalamus and the whole brain gray matter volume were evaluated by MMSE score, short delayed recall and long delayed recall. There was no correlation between reconfirmation and pattern recall score (P < 0.05). Conclusion the decrease of global gray matter volume in patients with chronic thalamic infarction may be the cause of cognitive impairment.
【作者单位】：重庆医科大学附属第一医院放射科;川北医学院基础医学院解剖教研室;
【基金】：国家临床重点专科建设项目(国卫办医函[2013]544号)
【分类号】：R743.33;R445.2
【正文快照】： ±32 886.53)mm3,(717 580.47±31 911.05)mm3,t=1.634,P=0.108]。梗死组全脑灰质体积与MMSE评分及图形回忆评分呈中度正相关(r=0.491、0.427,P=0.017、0.042);全脑灰质体积与短延迟回忆、长延迟回忆、再确认评分均无相关性(P均0.05);丘脑梗死体积与全脑灰质体积、MMSE评分、

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