靶Snake模型在早产儿脑室周围白质软化超声诊断中的应用研究

发布时间：2018-01-16 16:18

本文关键词：靶Snake模型在早产儿脑室周围白质软化超声诊断中的应用研究　出处：《中国临床医学影像杂志》2016年12期 　论文类型：期刊论文

【摘要】：目的:应用彩色多普勒超声与Snake模型图像分析软件,探讨超声灰度值定量分析对早产儿脑室周围白质软化(Periventricular leukomalacia,PVL)诊断的价值。方法:对生后7 d内临床诊断为PVL的早产儿120例及正常新生儿对照组80例进行常规颅脑超声检查,根据超声图像的灰度解剖分布,利用Snake模型图像分析软件自动提取实验感兴趣区,用"手动分析"进行边缘修正,从而提取被确定的5个感兴趣区(ROIs):基底节区、侧脑室前角旁脑白质、侧脑室后角旁脑白质、脉络丛和小脑蚓部。每个ROI标准切面连续录2幅图像进行数字化存储,用于离线分析,将每个相应结构的ROI描绘出来,并计算其平均的超声灰度值。对120例PVL早产儿实验数据进行可重复性(图像分析软件变异,EV)及可再现性(测量者变异,AV)的分析,用95%可信区间来反映其变异程度。结果:PVL患儿基底节区、侧脑室前角旁脑白质及侧脑室后角旁脑白质平均灰度值分别为130.64±4.12、131.35±3.02、133.46±2.94,高于对照组(92.51±6.89、81.64±2.78、85.75±3.65),差异有统计学意义(μ=44.49、119.78、97.57,P0.01);PVL患儿脉络丛、小脑蚓部平均灰度值分别为132.90±4.88、132.25±2.56,与对照组(131.98±5.82、131.43±4.47)无显著性差异。PVL患儿重复性EV为2.70%,再现性AV为0.56%,总的重复性及再现性变异(Repeatability and reproducibility,RR)为2.70%。结论:Snake模型脑组织灰度值定量分析评估,为临床早期诊断早产儿脑室周围白质软化提供了可靠的方法。
[Abstract]:Objective: to apply color Doppler ultrasound and Snake model image analysis software. Objective: to investigate the effect of quantitative analysis of ultrasound gray value on periventricular leukomalacia of premature infants with periventricular leukomalacia. Methods: 120 premature infants diagnosed as PVL within 7 days after birth and 80 normal newborns as control group were examined by routine craniocerebral ultrasound. According to the anatomical distribution of ultrasonic image, the Snake model image analysis software was used to automatically extract the experimental region of interest, and the edge was corrected by "manual analysis". Thus, five identified regions of interest, namely basal ganglia, white matter of the lateral anterior horn and white matter of the lateral posterior horn of the lateral ventricle, were extracted. Choroid plexus and vermis cerebellum. Two consecutive images of each ROI standard section were digitally stored for offline analysis and the ROI of each corresponding structure was depicted. The experimental data of 120 premature infants with PVL were analyzed for repeatability (image analysis software mutation) and reproducibility. Results the mean gray values of white matter in basal ganglia, paraventricular anterior horn and paraventricular posterior horn were 130.64 卤4.12, respectively. 131.35 卤3.02 卤133.46 卤2.94, higher than that of the control group (92.51 卤6.89) 81.64 卤2.78.85.75 卤3.65). The difference was statistically significant (渭 44.49) (119.78-97.57) (P 0.01); The mean gray values of choroidal plexus and vermis in children with PVL were 132.90 卤4.88 卤132.25 卤2.56 and 131.98 卤5.82 respectively. There was no significant difference (131.43 卤4.47). The repeatability of EV was 2.70 and the reproducibility of AV was 0.56% in children with PVL. Total reproducibility and reproducibility and reproducibility. Conclusion the quantitative evaluation of gray value of brain tissue in the brain tissue of the brain in the brain of the brain of the brain in the brain of the preterm infant provides a reliable method for the early diagnosis of periventricular leukomalacia in premature infants.
【作者单位】：广州市妇女儿童医疗中心超声科;
【分类号】：R742;R445.1
【正文快照】： 早产儿脑室周围白质软化(Periventricularleukomalacia,PVL)主要特征在于侧脑室周围深部脑白质的病变,是目前严重影响早产儿生存质量及导致小儿脑瘫的主要疾病[1]。头颅超声是使用最广泛的神经影像学检查方法。然而,在脑白质损伤后数日内以水肿为主的病理阶段,超声图像由于对

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