磁共振弹性成像与扩散加权成像在肝脏纤维化分期中的对比研究

发布时间：2018-01-29 09:06

本文关键词： 肝脏纤维化磁共振弹性成像扩散加权成像肝脏硬度　出处：《中国医学计算机成像杂志》2015年02期 　论文类型：期刊论文

【摘要】：目的:比较磁共振弹性成像(MRE)与扩散加权成像(DWI)在肝脏纤维化分期中的价值。方法:制备肝纤维化模型兔44只(其中32只作为试验组,12只作为预备组),正常对照组9只。对试验兔及正常对照兔行常规MRI、MRE及DWI,测量肝实质的硬度(LS)及ADC值。试验组实验兔皮下注射CCl4后的第4、5、6、10周分别随机选择8只行MRI扫描。以肝脏纤维化病理组织学诊断为标准,采用ROC曲线比较MRE和DWI对肝脏纤维化分期的诊断效能。结果:不同分期肝脏纤维化的LS及ADC值之间存在显著差异(P0.005)。MRE上测得的LS(r=0.838,P0.001)与肝脏纤维化分期的相关性比ADC值更强(r=-0.527,P0.001)。对于鉴别≥S1期及≥S2期,LS的曲线下面积(AUC)均明显大于ADC值的AUC(≥S1:0.979 vs.0.712,≥S2:0.922 vs.0.699)。MR E预测各期肝脏纤维化特异性高于DWI。结论:MR E所得LS与肝脏纤维化分期的相关性比DWI之ADC值更强,并且对预测各期肝脏纤维化均有较高的特异性。
[Abstract]:Objective: To compare magnetic resonance elastography (MRE) and diffusion weighted imaging (DWI) in the value of liver fibrosis stage. Methods: to prepare the rabbit model of hepatic fibrosis was 44 (including 32 as experimental group, 12 as a preparatory group), 9 rats in normal control group. The experimental rabbits and normal rabbits routine MRI, MRE and DWI, liver hardness (LS) and ADC value. The experimental group of experimental rabbit injection of CCl4 after 4,5,6,10 weeks were randomly selected 8 rats underwent MRI scanning. The liver fibrosis pathological diagnosis as the standard, the diagnostic efficacy of ROC curve comparison of MRE and DWI on liver fibrosis. Results: there were significant differences between different stages of liver fibrosis and LS ADC (P0.005).MRE values measured on LS (r=0.838, P0.001) and the correlation between the stages of liver fibrosis was stronger than ADC (r=-0.527, P0.001). For the identification of more than S1 and more than S2, the area under the LS curve (AUC ) were significantly greater than the ADC value of AUC (S1:0.979 = vs.0.712, S2:0.922 = vs.0.699).MR E forecast the liver fibrosis is more specific than DWI. conclusion: the correlation between stages of MR E with LS from liver fibrosis value is stronger than DWI ADC, and the specificity of the prediction of liver fibrosis were high.

【作者单位】：北京大学深圳医院医学影像科;香港大学深圳医院放射科;
【基金】：广东省科技局项目No.2001B031800385~~
【分类号】：R445.2;R575.2
【正文快照】： Chin Comput Med Imag,2015,21:176-1801 Department of Radiology,Peking University Shenzhen Hospital2 Department of Radiology,Hong Kong University Shenzhen HospitalAddress:1120 Lian Hua Rd.,Futian District,Shenzhen 518036,P.R.C.Address Correspondence to CHE

【共引文献】