比较TOF和PSF PET图像重建技术对肿瘤病灶定量参数的影响

发布时间：2018-01-31 00:45

本文关键词： 肿瘤正电子发射断层显像术　出处：《中国临床医学影像杂志》2017年08期 　论文类型：期刊论文

【摘要】：目的:对比分析TOF-PET和PSF-PET重建技术对全身不同部位及不同大小恶性肿瘤病灶18F-FDG代谢参数的影响。资料与方法:回顾性分析多中心原发恶性肿瘤接受18F-FDG PET/CT全身扫描病例共270例,男121例,女149例,平均年龄(59.07±11.82)岁(29~87岁);体质量指数(BMI)为23.92±3.35(16.61~34.34);胸部、腹部、盆腔及浅表部位恶性肿瘤分别为97、62、104和9例;病灶直径(Dmax)为(4.16±2.27)cm(0.5~15.2 cm)。将PET/CT数据VUE Point HD、TOF+VUE Point HD、Sharp IR+VUE Point HD及TOF+Sharp IR+VUE Point HD分别进行重建,其中VUE Point HD(GE Healthcare)为三维迭代重建技术,Sharp IR(GE Healthcare)是基于PSF技术原理的PET图像重建技术。应用AW工作站PET VCAR软件进行图像处理及测量18F-FDG代谢参数(SULmean、SULmax、SUVmean、SUVmax)并计算变化率(%)。应用独立样本t检验及One-way ANOVA分析TOF、PSF与TOF+PSF组代谢参数变化率的比较。结果:TOF和PSF对所有恶性肿瘤病灶的代谢参数均有提高,以TOF+PSF组最为显著。对于胸部病灶,PSF对SUVmax提高的百分比明显优于TOF,为8.96%vs 5.26%(P0.05);对于浅表部位病灶,PSF对SULmax、SUVmean及SUVmax提高的百分比明显优于TOF,分别为9.22%vs 1.22%、8.56%vs 1.78%及9.33%vs 1.11%(P0.05);对于盆腔病灶,TOF对SULmax、SUVmax提高的百分比则优于PSF,分别为18.72%vs 12.29%与20.69%vs 15.41%(P0.05);对于腹部病灶,TOF与PSF代谢指标提高无明显差异(P0.05)。BMI25组,TOF对SULmax、SUVmax提高的百分比也优于PSF,分别为10.45%vs 6.16%与10.27%vs 6.43%(P0.05)。Dmax≤2.0 cm组,PSF对SUVmax提高的百分比明显优于TOF,为11.68%vs 4.78%(P0.05)。对于BMI25组及Dmax2.0 cm组,两者对代谢参数的提高无明显差异。结论 :联合TOF+PSF组重建技术能显著提高恶性肿瘤病灶代谢参数,对于胸部、浅表部位病灶及较小病灶,PSF明显优于TOF;对于盆腔病灶及BMI25的患者TOF具有优势。
[Abstract]:Objective: to compare and analyze the effects of TOF-PET and PSF-PET reconstruction techniques on 18F-FDG metabolic parameters of malignant tumor lesions in different parts and sizes of the whole body. A total of 270 patients with multicenter primary malignant tumors underwent 18F-FDG PET/CT systemic scanning were retrospectively analyzed. There were 121 males and 149 females with an average age of 59.07 卤11.82 years old. The body mass index (BMI) was 23.92 卤3.35 (16.61g) and 34.34m (P < 0.05). The number of malignant tumors in chest, abdomen, pelvic cavity and superficial area were 97, 622, 104 and 9, respectively. The lesion diameter (D max) was 4.16 卤2.27 cm ~ (?) 0. 5 ~ 15. 2 cm ~ (-1). VUE Point HD was obtained from PET/CT data. TOF VUE Point HD. Sharp IR VUE Point HD and TOF Sharp IR VUE Point HD were reconstructed respectively. Where VUE Point HD(GE Healthcare is a 3D iterative reconstruction technique. Sharp IR(GE Healthcare). AW workstation PET VCAR software is used to process images and measure 18F-FDG metabolic parameters. TOF was analyzed by independent sample t-test and One-way ANOVA. Results the metabolic parameters of all malignant tumor lesions were increased by PSF and PSF. In TOF PSF group, the percentage of SUVmax increase was significantly higher than that in TOF group (8.96 vs 5.26P0.05). For superficial lesions, the percentage of SUVmax and SUVmean were significantly higher than that of TOF (9.22 vs 1.22%, respectively). 8.56 vs 1.78% and 9.33 vs 1.11; For pelvic lesions, TOF was superior to PSF in increasing the percentage of SUVmax. The values were 18.72 vs 12.29% and 20.69 vs 15.41, respectively. There was no significant difference in metabolic indexes between TOF and PSF in abdominal lesions. The percentage of increase of SUVmax in Tofs group was higher than that in PSF group. The values were 10.45 vs 6.16% and 10.27, respectively. The percentage of SUVmax increased by PSF was significantly higher than that by TOF (11.68 vs 4.78P0.05. for BMI25 and Dmax2.0 cm group). Conclusion: in combination with TOF PSF reconstruction technique, the metabolic parameters of malignant tumors can be significantly increased, for chest, superficial lesions and small lesions. PSF was superior to TOF. It is superior to TOF in patients with pelvic lesions and BMI25.
【作者单位】：中国医科大学附属盛京医院放射科;天津市肿瘤医院核医学科;内蒙古自治区人民医院核医学科;
【分类号】：R730.44
【正文快照】： 18氟-脱氧葡萄糖(18F-FDG)PET/CT利用图像融合技术将PET及CT配准、融合,目前广泛的应用于恶性肿瘤的确诊、治疗方案选择、疗效分析及预后分析中[1],利用不同的重建处理技术提高标准化摄取值(Standard uptake values,SUV)的准确性及图像质量至关重要。目前临床上PET/CT图像重建

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