原发性肝癌患者剪切波速度和超声造影定量参数与病理微血管密度关系研究

发布时间：2018-01-31 15:46

本文关键词： 肝肿瘤声触诊组织量化技术剪切波速度超声检查微血管　出处：《中国全科医学》2015年27期 　论文类型：期刊论文

【摘要】：目的探讨原发性肝癌患者病灶剪切波速度(SWV)、超声造影(CEUS)定量参数与病理微血管密度(MVD)的相关性。方法 2012年7月—2014年6月于中日友好医院行超声检查检出肝局灶性病变的187例患者中,选取经手术、病理证实的原发性肝癌患者39例(肝细胞肝癌35例,混合型肝癌3例,胆管细胞癌1例)为研究对象。术前采用声触诊组织量化技术(VTQ)获取病灶及病灶周围背景肝组织SWV,通过CEUS检查获取病灶及病灶周围背景肝组织CEUS定量参数(始增时间、始增强度、达峰时间、峰值强度、120 s回声强度、峰值加速时间、强度增量、增强速率和消退速率),并测定病灶及病灶周围背景肝组织MVD。结果病灶与病灶周围背景肝组织SWV分别为(2.84±0.68)m/s和(1.67±0.47)m/s,差异有统计学意义(t'=8.818,P0.001)。病灶始增时间、达峰时间、峰值加速时间以及120 s回声强度小于病灶周围背景肝组织(P0.05),病灶增强速率大于病灶周围背景肝组织(P0.05)。病灶始增强度、峰值强度、强度增量、消退速率与周围背景肝组织比较,差异无统计学意义(P0.05)。病灶与病灶周围背景肝组织MVD分别为(54.75±22.31)和(12.52±8.41),差异有统计学意义(t'=11.060,P0.001)。病灶SWV与MVD无线性相关关系(r=0.143,P=0.385)。病灶达峰时间、峰值加速时间与病灶MVD呈负相关(r=-0.632、-0.781,P0.05);病灶增强速率与MVD呈正相关(r=0.696,P0.05);病灶始增时间、始增强度、峰值强度、120 s回声强度、强度增量、消退速率与MVD无线性相关关系(P0.05)。结论 VTQ通过测定SWV可以定量评估原发性肝癌患者病灶组织硬度,但间接反映其血供的假设仍有待于更为深入的研究;原发性肝癌患者CEUS参数中的达峰时间、峰值加速时间、增强速率与MVD具有相关性,其在评估原发性肝癌患者血供方面具有良好的应用前景。
[Abstract]:Objective to investigate the primary lesions in patients with hepatocellular carcinoma and shear wave velocity (SWV), contrast-enhanced ultrasound (CEUS) quantitative parameters and microvessel density (MVD) correlation. Methods 187 cases from July 2012 to June 2014 in China-Japan Friendship Hospital for ultrasound detection of focal liver lesions in patients selected by surgery, pathology of primary 39 patients with liver cancer (35 cases, 3 cases of hepatocellular carcinoma, mixed hepatocellular carcinoma cholangiocarcinoma in 1 cases) as the research object. Vtq technique before the operation (VTQ) to obtain the liver tissue around the lesions and background SWV, CEUS quantitative parameters of liver tissue around the lesions and background obtained by CEUS examination (beginning by the time, began to increase strength, peak time, peak intensity, 120 s echo intensity, peak acceleration time, strength increment, enhancement rate and extinction rate), and liver tissue around the background lesions and MVD. results with the lesion week In liver tissue SWV were (2.84 + 0.68) m/s and (1.67 + 0.47) m/s, the difference was statistically significant (t'=8.818, P0.001). The lesion enhancement beginning time, peak time, peak acceleration time and 120 s echo intensity is less than the surrounding liver lesions (P0.05), the background of increasing rate is greater than the liver lesions tissue around the background lesions (P0.05). The lesion was enhanced and the peak strength, strength increment, extinction rate and liver tissue around the background, the difference was not statistically significant (P0.05). The liver tissue around the background with the lesion MVD respectively (54.75 + 22.31) and (12.52 + 8.41), the difference was statistically significant (t'=11.060 no, P0.001). The linear correlation between SWV and MVD lesions (r=0.143, P=0.385). The lesion peak time, peak acceleration time and the lesions were negatively correlated with MVD (r=-0.632, -0.781, P0.05); the enhancement rate and MVD showed positive correlation (r=0.696, P0.05); lesion enhancement beginning time, began to increase strength, peak The value of 120 s intensity, echo intensity, intensity increment, extinction rate and MVD linear correlation (P0.05). Conclusion VTQ was determined by SWV can quantitatively assess the primary lesion tissue of patients with hepatocellular carcinoma but its hardness, indirectly reflect the blood supply of the hypothesis remains to be further research; CEUS parameters in patients with primary liver cancer the peak time, peak acceleration time, increase rate is correlated with MVD, it has a good application prospect in the assessment of blood of patients with primary hepatocellular carcinoma for.

【作者单位】：中日友好医院超声科;中日友好医院病理科;
【基金】：首都卫生发展科研专项(首发2011-4012-01)
【分类号】：R735.7;R445.1
【正文快照】： Correlation Between Shear Wave Velocity,Quantitative Parameters of Contrast-enhanced Ultrasound and MicroVessel Density in Patients With Primary Liver Cancer XUE Wei,ZHAO Yu-zhen,HE Qi-jia,et al.Department ofUltrasound,China-Japan Friendship Hospital,Bei

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