MR扩散加权成像对甲状腺良恶性结节鉴别诊断价值的Meta分析

发布时间：2018-02-10 16:57

本文关键词： 甲状腺肿瘤磁共振成像扩散加权成像荟萃分析　出处：《放射学实践》2015年07期 　论文类型：期刊论文

【摘要】：目的:系统评价磁共振扩散加权成像(DWI)在甲状腺良、恶性结节鉴别诊断中的价值。方法:检索Cochrane library、Pubmed、Embase、Ovid、Medline数据库、中国生物医学文献数据库(CBM)、中国学术期刊全文数据库(CNKI)、维普中文科技期刊数据库(VIP)、万方数据知识服务平台自建库以来至2014年11月国内外公开发表的关于DWI应用于鉴别甲状腺结节良、恶性的中英文文献。按照诊断试验的纳入标准筛选文献,进行质量评价并提取特征信息。数据分析采用Meta-Disc 1.4和Stata 12.0软件,通过Meta分析合并诊断效应量及绘制受试者操作特征曲线(ROC)。结果:共纳入符合标准中英文文献13篇,纳入患者总数700名,病灶732个。不存在发表偏倚(P=0.70,P0.05),纳入文献质量高,DWI鉴别甲状腺结节良恶性的敏感度为0.90(95%CI:0.85~0.94),特异度为0.89(95%CI:0.84~0.93),诊断试验比值比为76.34(95%CI:42.98~135.58),阳性似然比为8.19(95%CI:5.50~12.20),阴性似然比为0.11(95%CI:0.07~0.17),受试者工作特征曲线下面积(AUC)和Q*指数分别为0.9365和0.8730。结论:DWI对甲状腺结节良、恶性的鉴别诊断有较高的准确性。
[Abstract]:Objective: to evaluate the value of diffusion-weighted magnetic resonance imaging (DWI) in the differential diagnosis of benign and malignant thyroid nodules. China Biomedical Literature Database (CBM), Chinese academic Journals full text Database (CNKI), Weipu Chinese Sci-tech Journals Database (VIPI), and Wanfang data knowledge Service platform (WDKS) have been published on DWI applications at home and abroad since November 2014. Differentiating thyroid nodules from benign ones, Malignant documents in both Chinese and English. Quality evaluation and feature information extraction were carried out according to the criteria included in the diagnostic test. The data were analyzed by Meta-Disc 1.4 and Stata 12.0 software. Results: 13 articles in English and Chinese were included in the standard, and 700 patients were included. There are 732 lesions. There is no publication bias. The sensitivity of DWI in identifying benign and malignant thyroid nodule is 0.90 ~ 95CI: 0.850.94, the specificity is 0.8995%, the ratio of diagnostic test is 76.3495 CI: 42.98 ~ 135.58, the positive ratio is 8.1995% CI 5.5012.20, the negative likelihood ratio is 0.1195 CI0.070.17, the ratio of diagnostic test is 76.3495 CI: 42.98, the positive ratio is 8.1995% CI 5.5012.20%, the negative likelihood ratio is 0.1195 CI0.070.17, the ratio of diagnostic test is 76.3495 CI: 42.98, the positive ratio is 8.1995% CI 5.5012.20%, the negative likelihood ratio is 0.1195 CI0.070.17, and the diagnostic test ratio is 76.3495 CI: 42.98% 135.58%. The area under the characteristic curve (AUC) and Q * index were 0.9365 and 0.8730 respectively. Malignant differential diagnosis has high accuracy.
【作者单位】：武汉大学人民医院放射科;武汉大学人民医院神经内科;
【分类号】：R445.2;R736.1

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