痉挛性斜颈患者静息态功能磁共振度中心度的研究

发布时间：2018-02-16 18:02

本文关键词： 痉挛性斜颈静息态功能磁共振度中心度　出处：《广西医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:既往多认为痉挛性斜颈(cervical dystonia,CD)发病与基底节功能异常相关,近年来多项研究发现其他脑区参与CD患者发病,但CD发病机制仍有待进一步明确,本研究采用度中心度方法比较CD患者组与正常对照组之间脑区功能连接差异,并探究CD的发病机制。方法:收集CD患者21例及与CD组年龄、性别等相匹配的健康志愿者21例,完善磁共振扫描,通过静息态功能磁共振技术(resting-state functional magnetic resonance imaging,rs-f MRI),采用度中心度测量方法(degree centrality,DC)比较患者与正常人之间功能连接差异,并将差异脑区的度中心度值与CD患者病程、症状严重程度行相关性分析。结果:与正常对照组相比,CD组度中心度显著增高的脑区为双侧楔前叶,而右侧眶部额中回显著性降低,上述差异脑区与CD患者病程、症状严重程度(Tsui评分)均无相关性(P值0.05)。结论:双侧楔前叶、右侧眶部额中回可能与CD不自主运动障碍的发病或者调控机制障碍有关;而CD患者病程、症状严重程度可能并不影响脑区之间的连接强度。
[Abstract]:Objective: it has been considered that the pathogenesis of spastic torticollis dystonia (CDCD) is associated with abnormal function of basal ganglia. In recent years, other brain regions have been found to be involved in the pathogenesis of CD, but the pathogenesis of CD remains to be further clarified. The purpose of this study was to compare the difference of functional connections between patients with CD and normal controls, and to explore the pathogenesis of CD. Methods: 21 patients with CD and 21 healthy volunteers matched with age and sex of CD group were collected. Using resting-state functional magnetic resonance imagingrs-f MRII, we compared the difference of functional connections between patients and normal subjects by using degree centralityDC. and compared the degree center values of different brain regions with the course of disease of CD patients. Results: compared with the normal control group, the bilateral anterior cuneate lobe was significantly increased in the CD group, while the middle frontal gyrus in the right orbital part was significantly decreased. The course of disease between the above different brain regions and CD patients was found to be significantly lower than that in the normal control group. There was no correlation between the severity of symptoms and Tsui score (P = 0.05). Conclusion: bilateral anterior cuneate lobe and right orbital middle frontal gyrus may be related to the pathogenesis or regulatory mechanism of CD involuntary motor disorder, while the course of CD patients is related to the course of disease. The severity of symptoms may not affect the intensity of connections between brain regions.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R445.2;R746

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