二维斑点追踪技术评价肺动脉高压大鼠左心室多维形变

发布时间：2018-02-20 02:41

本文关键词： 肺动脉高压心室功能左二维斑点追踪技术大鼠　出处：《中国医学影像技术》2015年08期 　论文类型：期刊论文

【摘要】：目的应用二维斑点追踪成像(2D-STI)技术评价肺动脉高压(PAH)大鼠左心室多维形变。方法将健康雄性SD大鼠50只,分为实验组(3、4、5、6周亚组)和对照组。实验组均按60mg/kg体质量皮下注射1%野百合碱,分别于建模3、4、5、6周后行超声心动图检查。对照组等比例注射生理盐水,24h后行超声心动图检查。常规二维超声测量左、右心功能参数,采用2D-STI测量左心室纵向、圆周及径向整体收缩期应变峰值(GSL、GSC和GSR)、收缩期应变率峰值(GSrL-S、GSrC-S和GSrR-S),并分析其与右心收缩功能指标的相关性。结果实验组大鼠右心功能逐步衰退,右心室壁厚度(RVWT)及右心室肥厚指数(RVHI)随周龄增大,右心室面积变化率(RVFAC)及三尖瓣瓣环收缩期位移(TAPSE)逐渐减低(P均0.05)。左心室射血分数和缩短率逐渐减低,其中5周及6周亚组与其他亚组和对照比较差异有统计学意义(P均0.05);与对照组相比,3周、4周、5周、6周亚组GSL、GSC和GSR均减低;GSrL-S、GSrC-S和GSrR-S亦减低,其中GSrL-S在3周时即表现出与对照组间的差异(P均0.05)。GSL、GSC、GSR、GSrL-S、GSrC-S和GSrR-S与RVFAC均呈正相关(P均0.05)。结论 2D-STI可观察PAH右心受损大鼠左心室的功能变化。
[Abstract]:Objective to evaluate the multi-dimensional deformation of left ventricle in PAH rats by two-dimensional speckle tracing imaging (2D-STI). Methods 50 healthy male Sprague-Dawley rats were used. The experimental group was divided into two groups: the control group and the experimental group. The experimental group was subcutaneously injected with 1% monocrotaline at 60 mg / kg body mass. The left and right ventricular function parameters were measured by conventional two-dimensional echocardiography, and the left ventricular longitudinal was measured by 2D-STI after 24 hours of normal saline injection in the control group, and the left ventricular function was measured by 2D-STI, and the left ventricular function was measured by 2D-STI, and the left ventricular function was measured by 2D-STI. The peak values of global systolic strain (GSL-GSC and GSRA) and the peak systolic strain rate of GSrL-Sn GSrC-S and GSrR-Sch were analyzed, and the correlation between them and the systolic function of the right heart was analyzed. Results the right cardiac function of the experimental group declined gradually. Right ventricular wall thickness (RVWTT) and right ventricular hypertrophy index (RVHII) decreased gradually with the increase of age, right ventricular area change rate (RVFAC) and tricuspid annular systolic displacement (TAPSE) decreased gradually, left ventricular ejection fraction (LVEF) and shortening rate decreased gradually. There was significant difference between the subgroup of 5 and 6 weeks and the other subgroups and the control group (P < 0.05), and the GSLL GSC and GSR of the subgroup of 3 weeks and 4 weeks and 5 weeks and 6 weeks were lower than those of the control group, and the GSrL-Sn GSrC-S and GSrR-S were also lower than those of the control group. The difference between GSrL-S and the control group at 3 weeks was 0.05U. GSLS GSR-GSrC-S and GSrR-S were positively correlated with RVFAC (P 0.05). Conclusion 2D-STI can observe the changes of left ventricular function in rats with PAH right heart damage.
【作者单位】：中国医科大学附属第一医院心血管超声科;辽宁医学院附属第一医院超声科;
【基金】：教育部高等学校博士学科点专项科研基金(20112104110010)
【分类号】：R544.1;R540.45

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