炎性肠病患者静息态功能磁共振成像低频振幅研究

发布时间：2018-02-21 15:54

本文关键词： 炎性肠病静息态功能磁共振低频振幅　出处：《医学研究生学报》2017年04期 　论文类型：期刊论文

【摘要】：目的炎性肠病患者内脏痛的发生可能与中枢神经系统对疼痛的异常处理有关,文中旨在采用低频振荡振幅(ALFF)算法静息态功能磁共振(rs-f MRI)研究炎性肠病患者脑功能改变的特点。方法收集2015年12月至2016年8月经南京医科大学第二附属医院消化科炎性肠病患者27例(病例组)和21例健康志愿者(对照组)。高分辨率结构像和rs-f MRI数据,通过ALFF分析方法对比2组患者脑功能活动的改变,观察病例组ALFF统计脑图与临床指标的相关性。结果与对照组比较,病例组内侧额回、右侧壳核、右侧岛叶、左中扣带回、双侧辅助运动区等区域ALFF值降低;额中回、左侧额上回、内侧前额叶等区域的ALFF值升高(P0.05)。病例组顶下小叶、楔前叶、左中扣带回ALFF值与血沉呈负相关(r=-0.537、-0.588、-0.588,P0.05);亦与病程、CRP呈负相关(P0.05)。内侧额回ALFF值与CRP呈正相关(r=0.623,P=0.001)。结论炎性肠病患者存在多个脑区ALFF值的异常,主要位于与内脏疼痛、情绪的处理相关脑区。
[Abstract]:Objective the occurrence of visceral pain in patients with inflammatory bowel disease may be related to the abnormal treatment of pain in the central nervous system. The purpose of this paper is to study the changes of brain function in patients with inflammatory bowel disease by using the low frequency oscillatory amplitude shift (ALFF) algorithm. Methods from December 2015 to 2016, the second affiliated Hospital of Nanjing Medical University was collected to study the characteristics of brain function changes in patients with inflammatory bowel disease. 27 patients with inflammatory bowel disease (case group) and 21 healthy volunteers (control group) had high resolution structural imaging and rs-f MRI data. The changes of brain function in two groups were compared by ALFF analysis, and the correlation between ALFF and clinical indexes was observed. Results compared with the control group, the patients had medial frontal gyrus, right putamen nucleus, right insular lobe, left middle cingulate gyrus, and left middle cingulate gyrus. The ALFF value of bilateral auxiliary motor area decreased, the ALFF value of middle frontal gyrus, left superior frontal gyrus and medial prefrontal lobe increased (P0.05). The ALFF value of left cingulate gyrus was negatively correlated with erythrocyte sedimentation rate (ESR), and negatively correlated with the course of disease (P 0.05). The ALFF value of medial frontal gyrus was positively correlated with CRP. Conclusion there are many abnormal ALFF values in brain regions in patients with inflammatory bowel disease, mainly in visceral pain. Emotional processing related brain regions.
【作者单位】：南京医科大学第二附属医院放射科;南京医科大学第二附属医院消化科;
【基金】：江苏省省级条件建设与民生科技专项资金(BL2014097) 南京医科大学科技发展基金重点项目(2015NJMUZD035)
【分类号】：R445.2;R574

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