白球比、门脉右支前间隙对肝纤维化的诊断对比研究

发布时间：2018-02-21 12:37

本文关键词： 肝硬化白球比门静脉病理学诊断价值　出处：《中国全科医学》2017年S2期 　论文类型：期刊论文

【摘要】：目的比较白球比(A/G)、门脉右支前间隙对肝脏纤维化的诊断价值。方法选取昆明医科大学第一附属医院2010年1月—2016年2月收治的肝纤维化患者98例,肝纤维化分期为S0期25例,S1期25例,S2期15例,S3期15例,S4期18例。采用病理检查及图像分析、血生化检查等,比较肝纤维化各分期A/G、门脉右支前间隙,并分析其与肝纤维化病理分期相关性,建立ROC曲线,分析A/G、门脉右支前间隙对肝纤维化S3、S4期的灵敏度、特异度。结果肝纤维化S1~S4期患者A/G值低于S0期,门脉右支前间隙高于S0期(P0.05);肝纤维化S4期患者A/G值低于S0期(P0.05);肝纤维化S3、S4期患者门脉右支前间隙高于S0期(P0.01)。A/G值、门脉右支前间隙与肝纤维化病理分期经Spearman相关性分析结果显示,肝纤维化各期与A/G值呈负相关(r=-0.275,P0.05),与门脉右支前间隙呈正相关(r=0.537,P0.001)。门脉右支前间隙对肝纤维化S3、S4期AUC高于A/G值,且门脉右支前间隙对肝纤维化S3、S4期诊断灵敏度、特异度较A/G高。结论门脉右支前间隙对肝纤维化分期≥S3期患者具有一定的诊断价值,而A/G值仅在肝纤维化分期≥S4期有明显改变,因此门脉右支前间隙对肝纤维化的诊断价值较A/G值高。
[Abstract]:Objective to compare the white ball ratio (A/G), the value of the right portal vein in diagnosis of liver fibrosis following clearance. 98 patients with liver fibrosis Methods First Affiliated Hospital of Kunming Medical University from January 2010 to February 2016 were patients, liver fibrosis stage S0 25 cases, S1 25 cases, S2 15 cases, S3 15 cases, stage S4 in 18 cases. The pathological examination and image analysis, blood biochemistry examination, comparison of liver fibrosis staging A/G, portal vein, anterior space of the right branch of, and to analyze the correlation between pathology and staging of hepatic fibrosis, A/G analysis to establish ROC curve, the portal vein of the anterior space of the right branch of liver fibrosis S3, S4 sensitivity and specificity. Results A/G patients with liver fibrosis S1~S4 value below S0, portal vein, anterior space of the right branch of higher than S0 phase (P0.05); A/G patients with liver fibrosis S4 value lower than S0 (P0.05); liver fibrosis S3, S4 patients with portal vein anterior space of the right branch was higher than that in stage S0 (P0.01).A/G, portal vein of the anterior space of the right branch and The pathological stages of liver fibrosis by Spearman correlation analysis showed that the liver fibrosis stages were negatively correlated with A/G (r=-0.275, P0.05), related to portal vein and anterior space of the right branch (r=0.537, P0.001). The positive portal anterior space of the right branch of hepatic fibrosis S3, S4 AUC higher than the A/G value, and the portal vein of the anterior space of the right branch hepatic fibrosis S3, S4 diagnostic sensitivity and specificity was higher than that of A/G. Conclusion the portal vein of the anterior space of the right branch has a certain value in diagnosis of liver fibrosis than S3 patients, while the A/G value changed significantly only in the stage of liver fibrosis than S4, so the portal vein of the anterior space of the right branch value for the diagnosis of liver fibrosis than A/G high value.

【作者单位】：昆明医科大学第一附属医院影像中心;
【分类号】：R445.2;R575.2

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