乳腺浸润性导管癌直接超声征象与雌激素受体和孕激素受体表达的关系研究

发布时间：2018-02-23 04:14

  本文关键词： 乳腺肿瘤 超声检查 受体 雌激素 孕激素类 分子生物学指标　出处：《中国全科医学》2016年27期 　论文类型：期刊论文

【摘要】：背景乳腺癌的治疗及预后与肿瘤的分子生物学指标表达密切相关。目的探讨乳腺浸润性导管癌直接超声征象与分子生物学指标雌激素受体(ER)、孕激素受体(PR)表达之间的关系。方法回顾性分析2014年12月—2015年4月首诊于新疆医科大学附属肿瘤医院并行手术的符合纳入标准的109例乳腺浸润性导管癌患者的临床资料。收集患者一般资料、免疫组化结果 (ER、PR表达情况)、超声检查结果 (病灶数量、病灶部位、病灶大小、分期、有无毛刺征、有无小分叶征、有无内部微钙化、有无后方回声衰减、纵横比、内部血流Adler分级)。结果 ER(+)75例(68.8%),PR(+)67例(61.5%),ER(-)34例(31.2%),PR(-)42例(38.5%)。单发病灶93例,多发病灶(病灶数量≥2个)16例;右乳48例,左乳61例;病灶位于外上象限51例,病灶位于内上象限27例,病灶位于外下象限16例,病灶位于内下象限15例;病灶最大径0.9~8.0 cm,平均病灶最大径(2.8±1.4)cm;T1期28例,T2期62例,T3期19例,T4期0例。ER(-)+PR(-)与非〔ER(-)+PR(-)〕患者病灶最大径比较,差异有统计学意义(P0.05)。乳腺癌直接超声征象中,内部血流Adler分级Ⅱ~Ⅲ级90例(82.6%),小分叶征58例(53.2%),内部微钙化58例(53.2%),毛刺征49例(45.0%),后方回声衰减49例(45.0%),纵横比≥0.71 41例(37.6%)。毛刺征、小分叶征、内部微钙化、后方回声衰减与ER、PR表达之间存在关联性(P0.05);纵横比、内部血流Adler分级与ER、PR表达之间互相独立(P0.05)。结论乳腺浸润性导管癌直接超声征象与ER、PR的表达有一定相关性,超声可以对乳腺癌进行治疗前评估及预后评价。
[Abstract]:Background the treatment and prognosis of breast cancer are closely related to the expression of molecular biological markers. Objective to investigate the expression of estrogen receptor ERA and progesterone receptor PRA in invasive ductal carcinoma of breast. Methods from December 2014 to April 2015, the clinical data of 109 breast invasive ductal carcinoma patients who were first diagnosed and operated at the affiliated Cancer Hospital of Xinjiang Medical University were analyzed retrospectively. The general data of the patients were collected. The results of immunohistochemistry were as follows: (number of lesions, location of lesions, size of lesions, stage, burr sign, small lobulation sign, internal microcalcification, back echo attenuation, aspect / aspect ratio), and the results of ultrasound examination (number of lesions, location of lesions, size of lesions, staging, no burr sign, internal microcalcification, posterior echo attenuation, ratio of aspect to aspect). Results Adler grading of internal blood flow was performed in 75 cases (68.8%). Results there were 34 cases (31.2%) with 31.2% PRA, 93 cases with single lesions, 16 cases with multiple lesions (the number of lesions 鈮，

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