重组人IL-11辅助治疗放射性口腔黏膜损伤效果观察

发布时间：2018-02-25 09:12

本文关键词： 口腔黏膜损伤重组人白细胞介素放射治疗放射性损伤　出处：《山东医药》2015年44期 　论文类型：期刊论文

【摘要】：目的探讨重组人IL-11辅助治疗放射性口腔黏膜损伤的临床效果。方法将128例头颈部恶性肿瘤患者随机分为观察组、对照组各64例。两组均行适形调强放疗,每周5次,每次2 Gy,总剂量70 Gy/35次。放疗期间均予常规口腔护理及雾化吸入,放疗开始饭前口服食管炎合剂10 m L,3次/天,至放疗结束;观察组在此基础上,三餐饭后30 min及睡前含服重组人IL-11配制液10 m L,4次/天,至放疗结束后10天。比较两组放疗第4、7周及放疗结束30天放射性口腔黏膜损伤程度。放疗结束后,比较两组出现疼痛时间及疼痛程度,口腔黏膜溃疡愈合时间及治疗中断情况。结果与对照组比较,观察组放疗第4、7周结束及放疗结束30天Ⅲ、Ⅳ度口腔黏膜损伤例数明显减少;口腔黏膜损伤出现疼痛时间较晚,疼痛程度较轻,溃疡愈合时间明显缩短,治疗中断例数明显减少(P均0.05)。结论重组人IL-11辅助治疗肿瘤放射性口腔黏膜损伤效果较好。
[Abstract]:Objective to investigate the clinical effect of adjuvant treatment of oral mucosal injury with recombinant human IL-11. Methods 128 patients with malignant tumor of head and neck were randomly divided into observation group (n = 64) and control group (n = 64). Each time 2 Gy, the total dose was 70 Gy/35. During radiotherapy, routine oral nursing and atomization inhalation were given, and 10 mL of esophagitis mixture was taken three times per day before the beginning of radiotherapy until the end of radiotherapy. The oral mucous membrane damage of the two groups was compared at the 7th week of radiotherapy and 30 days after radiotherapy, 30 min after meals and 4 times per day with 10 mL of recombinant human IL-11 mixture before bedtime, and the degree of oral mucosal damage after radiotherapy was compared between the two groups. The time and degree of pain, healing time of oral mucosa ulcer and treatment interruption were compared between the two groups. Results compared with the control group, the cases of oral mucosal injury in the observation group were significantly decreased at the end of the 7th week of radiotherapy and the end of 30 days after radiotherapy. The time of occurrence of oral mucosal injury was late, the degree of pain was lighter, the healing time of ulcer was shortened obviously, the number of treatment interruption was significantly reduced (P < 0.05). Conclusion the adjuvant treatment of oral mucosal injury with recombinant human IL-11 is effective.
【作者单位】：临沂市第三人民医院;临沂市肿瘤医院;
【分类号】：R730.55;R739.91

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