膀胱内翻性乳头状瘤和膀胱尿路上皮癌CEUS与微血管密度的相关性

发布时间：2018-02-26 07:01

本文关键词： 乳头状瘤内翻性膀胱尿路上皮癌微血管密度造影剂超声检查　出处：《中国医学影像技术》2017年05期 　论文类型：期刊论文

【摘要】：目的探讨膀胱内翻性乳头状瘤(IPB)与膀胱尿路上皮癌的(BUC)CEUS时间-强度曲线(TIC)参数与微血管密度(MVD)的相关性。方法回顾性分析经病理证实的IPB患者30例和BUC患者50例的临床和CEUS表现,采用QLab分析软件获得IPB和BUC的TIC参数,包括上升时间(RT)、平均渡越时间(MTT)、峰值强度(PI)、半洗漱时间(TPH)、上升斜率(WIS)、达峰时间(TP)、半降支斜率(DS),并进行统计学分析。对手术标本进行抗CD34因子免疫组化染色测量MVD,分析CEUS的TIC参数与MVD的相关性。结果 IPB和BUC的CEUS定量参数中,PI、TPH、TP、DS比较差异均有统计学意义(P0.05)。BUC的MVD明显高于IPB(P0.05)。各TIC参数中,TPH和DS与MVD均存在相关性(r_s=0.74、-0.81,P均0.05)。结论 CEUS在IPB与BUC的鉴别诊断中具有一定的临床价值;TIC参数可定量评估肿瘤内微血管生成情况。
[Abstract]:Objective to investigate the correlation between the time intensity curve of bladder inverted papilloma (IPB) and bladder urothelial carcinoma and microvessel density (MVD). Methods 30 cases of pathologically proved IPB and 50 cases of BUC were retrospectively analyzed. Clinical and CEUS findings, The TIC parameters of IPB and BUC are obtained by using QLab analysis software. It included rising time, average transit time, peak intensity, half wash time, rising slope, peak time, half descending branch slope, and statistical analysis. Immunohistochemical staining of anti CD34 factor was used to measure CD34. Results in the quantitative parameters of CEUS of IPB and BUC, there were significant differences in MVD between IPB and BUC. The MVD of P0.05, BUC was significantly higher than that of P0.05. The correlation between IPB, DS and MVD was significant (P < 0.05). Conclusion CEUS has a significant correlation with MVD (P = 0.05). It has some clinical value in the differential diagnosis of IPB and BUC.
【作者单位】：南昌大学第一附属医院超声科;
【基金】：江西省科技计划项目(2015BBG70234)
【分类号】：R445.1;R737.14

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