声学结构定量技术评估乙肝肝纤维化程度的临床价值

发布时间：2018-02-26 07:30

本文关键词： 声学结构定量技术肝纤维化 Fibroscan　出处：《中国超声医学杂志》2015年01期 　论文类型：期刊论文

【摘要】：目的通过对乙肝患者肝脏声学结构定量(ASQ)分析与病理及Fibroscan结果对比,初步探讨ASQ技术对乙肝肝纤维化分期的诊断价值。方法收集在我院确诊为慢性乙型肝炎患者66例,进行ASQ分析和Fibroscan检查,继之行肝脏穿刺活检。结果随着肝纤维化程度的增加,ASQ定性分析彩色编码图表现为黄绿色区减少,红色区域增加,且不规则;ASQ定量分析图表现为红色曲线峰值变小,蓝色曲线峰值变大,曲线下面积增大。ASQ定量参数BR-Ratio值在各组之间均有显著性差异(P0.05)且与肝纤维化分期有较好正相关(r=0.772,P0.05),当S≥1、S≥2、S≥3、S≥4时BR-Ratio值的曲线下面积(AUC)分别为0.832、0.913、0.962、0.974;BR-Ratio值区分S≥1、S≥2、S≥3、S≥4的截断值分别为0.33、0.37、0.49、0.55。对ASQ及Fibroscan的AUC进行比较,P均0.05。结论 ASQ技术对肝纤维化程度的诊断价值与Fibroscan相近,在肝纤维化定量诊断中具有潜在的临床应用前景。
[Abstract]:Objective through the liver of patients with hepatitis B ASQ (ASQ) compared with pathology and Fibroscan results, evaluate the value of staging ASQ on hepatitis B Hepatic fibrosis. Methods in our hospital diagnosed 66 cases of patients with chronic hepatitis B, ASQ analysis and Fibroscan examination, followed by liver biopsy. Results with the increase of the degree of liver fibrosis, ASQ qualitative analysis of color encoding images reduced to yellow green, red area increased, and irregular; the quantitative analysis of ASQ showed the red curve peak becomes smaller, the blue peak becomes larger, the area under the curve increased. There were significant differences between the groups in.ASQ quantitative parameters BR-Ratio value (P0.05) and and the staging of liver fibrosis has a good positive correlation (r=0.772, P0.05), when S = 1, S = 2, S = 3, S = 4 BR-Ratio area under the curve (AUC) were 0.832,0.913,0.962,0.974; BR-Ratio value S = 1, S = 2, S = 3, S = 4, the cutoff value were compared respectively on 0.33,0.37,0.49,0.55. ASQ and Fibroscan AUC, P 0.05. conclusion ASQ technique for liver fibrosis diagnosis and Fibroscan were similar, with the prospect of potential clinical application in quantitative diagnosis of liver fibrosis.

【作者单位】：昆明医科大学第一附属医院超声科;
【分类号】：R445.1;R512.62;R575.2

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