超声造影在困难部位恶性肿瘤放射性粒子植入治疗中的应用价值

发布时间：2018-02-26 22:35

本文关键词： 超声造影放射性粒子植入治疗恶性肿瘤　出处：《中山大学学报(医学科学版)》2015年01期 　论文类型：期刊论文

【摘要】：【目的】探讨超声造影(CEUS)在困难部位恶性肿瘤放射性粒子植入治疗中的应用价值。【方法】超声造影引导下对24例共31个困难部位(肿瘤边缘与胆囊、肝门部、胃肠、左右门静脉主干或三支肝静脉、下腔静脉距离不足0.5 cm)的恶性肿瘤行放射性碘粒子植入治疗术。分别于术前和术后1、3、6、12月进行增强CT及超声造影随访。根据RECIST判定标准评价局部疗效,根据超声造影早期增强程度评估病灶血供变化。【结果】平均随访时间11个月,范围1~46个月。增强CT显示术后1、3、6、12月总有效率分别为0%、7.7%、21.1%及54.6%。超声造影显示术后1、3、6、12月富血供病灶所占比例分别为89.7%、50.0%、36.8%及27.3%。无严重并发症及粒子植入相关死亡发生。【结论】超声造影在困难部位恶性肿瘤放射性粒子植入治疗中能安全有效地引导放射性粒子的植入,对肿瘤局部疗效的评判也具有一定的帮助。
[Abstract]:[objective] to evaluate the value of contrast-enhanced ultrasound (CEUs) in the treatment of malignant tumors with radioactive seeds implantation in difficult areas. [methods] Twenty-four patients with 31 difficult sites (tumor edge and gallbladder, hilar hepatis, gastrointestinal tract) were treated by contrast-enhanced ultrasound. Main portal vein or three hepatic veins, Radioactive iodine seed implantation was performed on malignant tumors with inferior vena cava (less than 0. 5 cm). Enhanced CT and contrast-enhanced ultrasonography were performed before and after operation, respectively, on December. The local efficacy was evaluated according to RECIST criteria. The changes of blood supply were evaluated according to the early enhancement of contrast-enhanced ultrasound. [results] the mean follow-up time was 11 months. The range was 1 ~ 46 months. The total effective rate of CT was 0 and 7.721% and 54.6%, respectively. Contrast-enhanced CT showed that the proportion of lesions with rich blood supply in December was 89.70.30% and 27.33.Conclusion there were no serious complications and death associated with seed implantation. [[conclusion] there are no serious complications and death associated with seed implantation. [conclusion] there are no serious complications and death associated with seed implantation. [conclusion] there are no serious complications and death associated with seed implantation. [conclusion] there are no serious complications and death associated with seed implantation. Contrast-enhanced ultrasound can guide the implantation of radioactive particles safely and effectively in the treatment of malignant tumor in difficult position. It is also helpful to evaluate the local curative effect of tumor.
【作者单位】：中山大学附属第一医院超声波科;中山大学附属第一医院检验医学部;
【基金】：国家自然科学基金(81371555) 广东省医学科研基金(A2013194)
【分类号】：R445.1;R730.5

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