体素内不相干运动成像与三维动脉自旋标记成像评估缺血性脑梗死脑血流灌注的对比研究

发布时间：2018-02-27 17:48

本文关键词： 动脉自旋标记成像脑血流量磁共振体素内不相干运动成像　出处：《上海交通大学学报(医学版)》2015年12期 　论文类型：期刊论文

【摘要】：目的对比分析体素内不相干运动成像(IVIM-MRI)与三维动脉自旋标记成像(3D-ASL)在评价缺血性脑梗死后脑血流灌注改变中的临床应用价值。方法 46例缺血性脑梗死患者分别行常规MRI、弥散加权成像(DWI)、3D-ASL和IVIM-MR检查。以DWI显示的梗死灶和镜像对照区作为感兴趣区,3D-ASL分别测量双侧局部脑血流量(CBF)变化。IVIM测量参数有表观扩散系数(ADC)、灌注分数(f)、假扩散系数(D*)以及扩散系数(D),将患侧与健侧参数进行配对t检验。同时计算所有参数的相对值(r=脑梗死区/健侧镜像区),同时将IVIM各参数相对值改变(r ADC、rf、rD*、rD)分别与r CBF进行Spearman相关性分析。结果梗死区CBFASL较对侧减低,两者差异有统计学意义(P0.05)。梗死区ADC、f值、D值与健侧比较的差异有统计学意义(P0.05)。梗死区D*值较健侧减低,但差异无统计学意义(P0.05)。除rD*外,梗死区r ADC、rD、rf与rCBF的相关性具有统计学意义(P0.05)。结论 IVIM-MR和3D-ASL在检出缺血性脑梗死患者的脑血流灌注改变方面具有一致性,可用于评价缺血性脑梗死后血流灌注改变,有利于指导临床。
[Abstract]:Objective to compare the clinical value of IVIM-MRI and 3D-ASL in evaluating cerebral blood perfusion after ischemic cerebral infarction. Methods 46 patients with ischemic cerebral infarction were treated with IVIM-MRI and 3D-ASL respectively. Conventional MRI, DWI 3D-ASL and IVIM-MR were performed. The changes of bilateral regional cerebral blood flow (CBF) were measured by using the infarcted area and mirrored control area as the area of interest, respectively. The parameters of IVIM measurement were as follows: apparent diffusion coefficient and perfusion fraction. The parameters of the affected side and the healthy side were matched by t test. The relative values of all parameters were calculated at the same time: r = cerebral infarction area / contralateral mirror area, and the relative values of each parameter of IVIM were changed respectively with the. R CBF was used for Spearman correlation analysis. Results CBFASL in infarct area was lower than that in contralateral side. The difference between the two groups was statistically significant (P < 0.05). The difference of ADCF value and D value between infarcted area and healthy side was statistically significant (P < 0.05). The D* value in infarct area was lower than that in healthy side, but the difference was not statistically significant (P 0.05), except for rD*, there was no significant difference between the two groups. Conclusion IVIM-MR and 3D-ASL are consistent in detecting cerebral blood flow perfusion in patients with ischemic cerebral infarction, and can be used to evaluate the changes of blood flow perfusion after ischemic cerebral infarction. It is helpful to guide clinical practice.
【作者单位】：上海交通大学医学院附属仁济医院南院放射科;上海交通大学医学院附属仁济医院放射科;安徽医科大学第一附属医院放射科;
【基金】：上海交通大学医工交叉基金面上项目(YG2014MS50) 上海市卫计委面上项目(201540231) 上海交通大学医学院附属仁济医院南院科研启动基金(2014QDM12)~~
【分类号】：R743.3;R445.2

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