NADPH氧化酶p22phox亚基C242T基因多态性与中国朝鲜族高血压患者左心室肥厚的相关性

发布时间：2018-03-01 15:09

本文关键词： 高血压 NADPH氧化酶pphox亚基朝鲜族基因多态性左心室肥厚　出处：《实用医学杂志》2015年18期 　论文类型：期刊论文

【摘要】：目的:探讨NADPH氧化酶p22phox亚基(NADPH oxidase subunit p22phox,NOSP)C242T基因多态性与中国朝鲜族人群原发性高血压(EH)患者发生左心室肥厚(LVH)的相关性。方法:选取正常朝鲜族对照者108例及初诊为EH朝鲜族患者231例,应用聚合酶链反应对所有受试者NOSP 242位点进行基因型分析。231例EH患者再分为EH和EH+LVH组,超声心动图评估患者左心室质量指数,并测定生化指标。结果:NOSP 242位点基因多态性在对照组和EH组中的分布无明显差异;EH组和EH+LVH组中,CC与CT+TT比较,基因分布存在明显差异;CC型EH患者合并LVH的风险高于CT及TT型患者。结论:NOSP C242T基因多态性与朝鲜族EH患者无关。NOSP C242T基因多态性与EH合并LVH相关,CC基因是朝鲜族EH患者合并LVH的风险因素。
[Abstract]:Objective: to investigate the relationship between the polymorphism of NADPH oxidase p22phox subunit, NADPH oxidase subunit p22phoxSNP C242T gene and the incidence of left ventricular hypertrophy (LVH) in patients with essential hypertension (EH) in Chinese Korean population. 231 cases of EH Korean patients, Polymerase chain reaction (PCR) was used to analyze the genotype of NOSP 242 locus in all subjects. 231 EH patients were subdivided into EH and EH LVH groups. The left ventricular mass index (LVMI) was evaluated by echocardiography. Results there was no significant difference in the distribution of gene polymorphism at NoSP242 locus between control group and EH group. There was no significant difference between CC and CT TT in EH group and EH LVH group, and there was no significant difference between CC and CT TT in EH group and EH LVH group. There was significant difference in gene distribution between CC type EH patients and LVH patients. Conclusion there is no relationship between the polymorphism of the 10% NOSP C242T gene and the Korean EH patients. The polymorphism of NOSP C242T gene and the EH associated with LVH gene are associated with EH of Korean nationality. Risk factors for patients with LVH.
【作者单位】：延边医院电诊科;延边医院内分泌科;
【基金】：国家自然科学基金(编号:30460053)
【分类号】：R544.1;R540.45

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