拉伸指数模型DWI在鉴别肾乏脂性错构瘤与乳头状肾细胞癌临床价值

发布时间：2018-03-19 14:54

本文选题：拉伸指数模型　切入点：肾乏脂性错构瘤　出处：《临床放射学杂志》2017年06期 　论文类型：期刊论文

【摘要】：目的评估拉伸指数模型扩散加权成像(DWI)参数在鉴别肾脏乏脂性错构瘤与乳头状细胞癌临床价值。方法回顾性分析47例经手术病理证实肾乏脂性错构瘤(n=21)与乳头状肾细胞癌(n=26)患者临床资料,所有患者在3.0 T MRI采用多b值DWI(b=0~1700 s/mm~2)进行扫描。基于拉伸指数模型计算相应的定量参数[扩散分布系数(DDC),扩散异质性(α)]值。在两者之间鉴别采用独立样本t检验进行分析,采用组内相关系数(ICC)及接受者工作特征曲线(ROC)进行统计评估。结果与肾乏脂性错构瘤[DDC=(3.061±2.729)×10~(-3)mm~2/s]相比,肾乳头状细胞癌中DDC明显降低[DDC=(0.953±0.417)×10~(-3)mm~2/s,P0.001],而α值(α=0.776±0.113)明显高于乏脂性错构瘤(α=0.412±0.088,P0.001)。拉伸指数模型DWI定量参数值在两者之间鉴别诊断的曲线下面积(AUC)、敏感性、特异性和最佳截止值分别为:α:0.998、96.3%、100.0%、0.595;DDC:0.882、91.3%、74.1%、1.202×10~(-3)mm~2/s。结论肾乏脂性错构瘤与乳头状肾细胞癌具有不同的拉伸指数扩散定量参数值;α值在鉴别两者具有较高的诊断效能。
[Abstract]:Objective to evaluate the clinical value of DWI parameters in differentiating renal hypolipidemic hamartoma from papillary cell carcinoma. Methods 47 cases of renal hypolipidemic hamartoma proved by surgery and pathology were retrospectively analyzed. Clinical data of patients with renal cell carcinoma. All patients were scanned at 3.0T MRI with multiple b DWI(b=0~1700 s / mmm2). The corresponding quantitative parameters were calculated based on the stretching index model [diffusion distribution coefficient (DDC), diffusion heterogeneity (伪)]. Independent sample t test was used to analyze the difference between the two. The results were compared with that of renal hypolipidemic hamartoma (DDC=(3.061 卤2.729) 脳 10 ~ (-3) mm ~ (-3) / s, compared with that of renal hypolipidemic hamartoma (DDC=(3.061 卤2.729) 脳 10 ~ (-3) mm ~ (-3) / s. DDC was significantly decreased in renal papillary cell carcinoma [DDC=(0.953 卤0.417) 脳 10 ~ (-3) mm ~ (-2) 路s ~ (-1) P ~ (0.001)], and 伪 value (伪 ~ (0.776 卤0.113)) was significantly higher than that of hypolipidemic hamartoma (伪 _ (0.412 卤0.088) P _ (0.001)). The specificity and the best cut-off value were: 伪: 0.998 / 96.3and 100.00.595DDCW 0.882/ 91.3 / 74.1and 1.202 脳 10 ~ (-3) mm ~ (-2) / s respectively. Conclusion there are different quantitative parameters of extension index diffusion between renal hypolipidemic hamartoma and papillary renal cell carcinoma, and a value has higher diagnostic efficacy in differentiating them.
【作者单位】：华中科技大学同济医学院附属同济医院放射科;
【分类号】：R445.2;R737.11

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