胆红素脑病所致听力受损患儿听觉通路纤维束的DTI研究:各向异性分数和其他扩散系数的变化

发布时间：2018-03-20 13:28

本文选题：扩散张量成像　切入点：胆红素脑病　出处：《临床放射学杂志》2017年11期 　论文类型：期刊论文

【摘要】：目的运用磁共振扩散张量成像(DTI)技术,探讨胆红素脑病所致听力受损患儿听觉通路纤维束各DTI参数的改变。方法运用德国Siemens公司3.0 T超导磁共振扫描仪(Siemens 3.0 T Skyra)对27例胆红素脑病患儿和40例对照组患儿进行DTI检查,选择研究对象听觉通路上外侧丘系和下丘两个感兴趣区域测量相关参数,对所得参数进行相关的统计分析。结果听力受损组与对照组比较、单侧听力受损组的受损侧与未受损侧比较均为各向异性分数(FA)降低、轴向扩散系数(RD)升高,且差异具有统计学意义,其他组两两比较中结果无显著差异;另外在外侧丘系和下丘两区域FA值与听觉阈值存在线性负相关性,而DTI其他参数与听觉阈值之间均无线性相关性。结论基于DTI技术的纤维束成像能够直观地反映脑内白质纤维束的形态,听力受损患儿DTI的部分参数变化明显,提示患儿脑白质纤维束髓鞘的破坏或发育不良,但是纤维束以及轴突的完整性未破坏。
[Abstract]:Objective to apply the diffusion imaging technique of magnetic resonance diffusion imaging (DTI), To investigate the changes of DTI parameters of hearing pathway fiber bundle in children with hearing impairment caused by bilirubin encephalopathy, DTI was performed in 27 children with bilirubin encephalopathy and 40 children in control group by using Siemens 3.0T superconducting magnetic resonance scanner. Two regions of interest in the auditory pathway, the superior lateral colliculus and the inferior colliculus, were selected to measure the relevant parameters, and the parameters were statistically analyzed. Results the hearing loss group was compared with the control group. In unilateral hearing loss group, the anisotropic fraction (FAA) was decreased and the axial diffusion coefficient (RD) was increased, and the difference was statistically significant. There was no significant difference in the results between the other two groups. In addition, there was a negative linear correlation between FA value and auditory threshold in lateral colliculus and inferior colliculus. However, there was no linear correlation between other parameters of DTI and auditory threshold. Conclusion Fiber-bundle imaging based on DTI technique can directly reflect the morphology of white matter fiber bundle in brain, and some parameters of DTI in children with hearing impairment have obvious changes. The results suggest that the myelin sheath of white matter bundle is damaged or dysplasia, but the integrity of fiber bundle and axon is not destroyed.
【作者单位】：湖南省儿童医院放射科;
【分类号】：R445.2;R742

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