三维斑点追踪技术评价家族性肥厚型心肌病MYBPC3基因突变携带者左心室功能的早期改变

发布时间：2018-03-21 13:09

本文选题：肥厚型心肌病　切入点：三维斑点追踪技术　出处：《中国超声医学杂志》2017年09期 　论文类型：期刊论文

【摘要】：目的应用三维斑点追踪(3D-STE)技术评价家族性肥厚型心肌病(FHCM)家系中MYBPC3基因突变携带者成人左心室功能的早期改变。方法纳入MYBPC3-HCM者G+/P-者27例,对照组为G-/P-者50例。对所有研究对象行常规2D、TDI及3D-STE分析,比较两组差异。结果与G-P-组相比,G+P-组左心室GLS、GRS、e′与e′/a′显著降低,而EDT显著延长,E/e′显著升高,ROC分析显示:GLS为-21.78%诊断MYBPC3-HCM基因突变携带者的灵敏度为78%、特异度为60%(AUC=0.702)。结论 MYBPC3-HCM者中G+P-组早期已出现了左心室功能异常,3D-STE为早期评价MYBPC3-HCM携带者的左心室功能提供依据。
[Abstract]:The purpose of the application of three-dimensional speckle tracking (3D-STE) technique for the assessment of familial hypertrophic cardiomyopathy (FHCM) early changes in MYBPC3 family gene mutation carriers in patients with left ventricular function. Methods a total of 27 cases of MYBPC3-HCM G+/P-, the control group was G-/P- in 50 cases. All subjects underwent conventional 2D analysis, TDI and 3D-STE, the difference the two groups were compared. Results compared with G-P- group, G+P- group, left ventricular GLS, GRS, e 'and E' /a 'was significantly decreased, while EDT was significantly prolonged, E/e' increased significantly, ROC analysis showed that GLS -21.78% for diagnosis of MYBPC3-HCM gene mutation carriers sensitivity was 78%, specificity was 60% (AUC=0.702). Conclusion MYBPC3-HCM in the early G+P- group appeared abnormal left ventricular function, 3D-STE provide the basis for early evaluation of left ventricular function with MYBPC3-HCM.

【作者单位】：宁夏医科大学;第四军医大学西京医院超声科;宁夏医科大学总医院心脏中心功能检查部超声心动图室;
【基金】：科技部国家国际合作专项(No.2014DFA31980) 国家自然科学基金面上项目(No.81671693);国家自然科学基金青年项目(No.81501472) 陕西省重点项目(No.S2017-ZDYF-ZDXD-SF-0123)
【分类号】：R540.45;R542.2

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