针刺重性抑郁症患者百会穴后脑功能区低频振幅的变化

发布时间：2018-03-21 13:41

本文选题：针刺　切入点：百会穴　出处：《临床放射学杂志》2015年06期 　论文类型：期刊论文

【摘要】：目的探讨首发未治疗重性抑郁症(MDD)患者经针刺百会穴(GV20)后脑功能区的低频振幅(ALFF)变化。方法将16例首发未治疗MDD患者依据针刺真假情况,分别纳为GV20组和假穴组,另将20名健康自愿者纳为对照组。于针刺真、假穴前后分别行静息态f MRI扫描,应用ALFF方法分析受试者脑功能区变化情况。并采用统计学方法,检验GV20组与另两组间ALFF变化的差异。结果针刺前,GV20组ALFF值较对照组升高的区域主要位于右侧前、中扣带回、豆状核、楔前叶及两侧岛叶,降低的区域主要位于两侧海马、小脑及枕叶;针刺真、假穴后,与假穴组对比,GV20组右侧前、中扣带回、豆状核及左侧岛叶ALFF值降低,左侧海马、小脑ALFF值升高,与针刺前相应异常脑区的变化相反。结论针刺GV20可能对MDD患者部分异常的脑功能区有调节作用。基于f MRI技术的ALFF算法可为探索针刺治疗MDD的中枢机制提供潜在的影像学证据。
[Abstract]:Objective to investigate the changes of low frequency amplitude of ALF in brain functional area after acupuncture at Baihui Point GV20 in patients with first-episode untreated major depressive disorder (MDD). Methods Sixteen patients without initial treatment of MDD were divided into GV20 group and sham point group according to the true and false situation of acupuncture. In addition, 20 healthy volunteers were taken as the control group. The rest f MRI scanning was performed before and after acupuncture at Zhenzhen and pseudo acupoints. The changes of brain functional areas were analyzed by ALFF method, and the changes of brain functional areas were analyzed by statistical method. Results compared with the control group, the increase of ALFF in the GV20 group was mainly located in the right anterior cingulate gyrus, the lentiform nucleus, the anterior cuneate lobe and the bilateral insular lobe, and the decreased area was mainly located in the bilateral hippocampus. The ALFF values of the right anterior, middle cingulate gyrus, lentiform nucleus and left insular lobe decreased, while the ALFF values of the left hippocampus and cerebellum increased in the cerebellum and occipital lobe after acupuncture. Conclusion Acupuncture GV20 may regulate some abnormal brain functional areas in patients with MDD. The ALFF algorithm based on f MRI technique can provide potential imaging evidence for exploring the central mechanism of acupuncture treatment of MDD.
【作者单位】：广西中医药大学第一附属医院放射科;广西中医药大学第一附属医院神经内科;广西中医药大学第一附属医院针灸科;
【基金】：广西自然科学基金项目(编号:2011GXNSFA018176) 广西教育厅基金项目(编号:200911LX200)
【分类号】：R246.6;R445.2

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