产前诊断唇腭裂畸形的研究进展

发布时间：2018-03-25 13:14

本文选题：唇腭裂　切入点：产前诊断　出处：《口腔医学研究》2017年01期

【摘要】：唇腭裂是胎儿颜面部最常见的先天性畸形,一半的病例为唇裂合并腭裂,可以孤立存在,也可合并与一些先天性畸形合并存在。由于唇腭裂畸形影响新生儿面容、吸吮、吞咽、语言及面部发育等功能,导致身心发育不良,给患儿和家庭带来不良影响。产前早期诊断胎儿唇腭裂畸形有利于孕妇得知胎儿患有唇腭裂畸形后向产科、儿科及正畸专家咨询及时作出是否继续妊娠的选择。产前超声检查是早期诊断唇腭裂最主要及最重要的筛选及诊断方法,并可进行唇腭裂分型并系统检查胎儿是否有其它器官合并畸形;胎儿磁共振对超声发现的唇腭裂特别是腭裂的诊断和严重程度评估上起辅助诊断作用。产前优生遗传检查可确定唇腭裂胎儿是否合并有染色体异常。
[Abstract]:Cleft lip and palate is the most common congenital malformation in the face of fetus. Half of the cases are cleft lip with cleft palate, which can exist in isolation or with some congenital deformities. Language, facial development and other functions lead to poor physical and mental development, and have adverse effects on children and families. Early prenatal diagnosis of fetal cleft lip and palate malformation can help pregnant women to know that their foetus has cleft lip and palate malformation and then go to obstetrics. Pediatricians and orthodontists make timely choices as to whether to continue pregnancy. Prenatal ultrasound is the most important and important screening and diagnosis method for early diagnosis of cleft lip and palate. Cleft lip and palate can be classified and the fetus can be examined systematically for other organs complicated with malformation. Fetal magnetic resonance plays an auxiliary role in the diagnosis and evaluation of cleft lip and palate, especially in the evaluation of the severity of cleft palate. Prenatal genetic examination can determine whether the fetus with cleft lip and palate has chromosomal abnormalities.
【作者单位】：湖北省妇幼保健院超声科;武汉大学口腔医学院;
【基金】：湖北省自然科学基金资助(编号:2014CFB210)
【分类号】：R714.5;R445.1

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