多b值DWI对艾滋病家庭孤儿基底节扩散差异的研究

发布时间：2018-03-25 19:50

本文选题：单指数模型　切入点：拉伸指数模型　出处：《放射学实践》2015年07期

【摘要】：目的:探讨单指数模型和拉伸指数模型下多b值扩散加权成像(DWI)对HIV阳性的诊断价值。方法:23名来自艾滋病家庭青少年孤儿,其中15例HIV阳性感染者、8例HIV阴性健康者。对所有研究对象行脑部多b值(0、50、150、200、400、600、800s/mm2)DWI检查。利用单指数模型和拉伸指数模型拟合出脑部基底节区表观扩散系数(ADC)、分布扩散系数(DDC)、异质性指数(α)后行统计学分析。结果:两种模型均能较好描述出多b值DWI中体素内信号强度随b值增加而递减的特征;HIV阳性感染者左侧基底节区α值(0.848±0.068)较阴性健康者(0.923±0.050)明显下降(t=-2.749,P=0.012),两组右侧基底节区α值差异无统计学意义(P0.05)。两组间DDC值和ADC值差异均无统计学意义(P均0.05)。各组基底节区DDC值与ADC值之间均呈正相关性(HIV阳性感染者基底节区:左侧r=0.770,P=0.001,右侧r=0.832,P=0.000;HIV阴性健康者基底节区:左侧r=0.878,P=0.004,右侧r=0.927,P=0.001)。结论:拉伸指数模型DWI中的α值有可能作为评价指标来鉴别HIV阳性和HIV阴性,对HIV阳性的诊断提供有价值的参考。
[Abstract]:Objective: to investigate the diagnostic value of multiple b value diffusion-weighted imaging (DWI) under single index model and stretch index model in the diagnosis of HIV positive. Among them, 15 cases were positive for HIV infection and 8 cases were HIV negative healthy people. All the subjects were examined with multivariate b value of 050150200400400800s / mm2DWI. The apparent diffusion coefficient of basal ganglia of brain was fitted by single index model and stretching index model, and distributed diffusion was obtained by using single index model and stretching index model. Results: both models were able to describe the signal intensity of voxel decreased with the increase of b value in the left basal ganglia of HIV-positive patients (0.848 卤0.068). There was no significant difference in the 伪 value of right basal ganglia between the two groups (P 0.05). There was no significant difference in DDC and ADC between the two groups (P < 0.05). There was a positive correlation between DDC and ADC in the basal ganglia of each group. In the positive cases, the basal ganglia region of the infected patients was: the left side was 0.770.70, the right side was 0.832P 0.000, and the right side was the basal ganglia of the HIV-negative healthy subjects: the left side was 0.878G / P 0.004, and the right side was 0.927m / P0.001p0.0010.Conclusion: the 伪 value in the stretching index model DWI may be used as an evaluation index to distinguish the HIV positive from the HIV negative. It provides a valuable reference for the diagnosis of HIV positive.
【作者单位】：武汉大学物理科学与技术学院;武汉大学中南医院医学影像科;
【基金】：医科达医疗器械(上海)公司对本课题的资助与支持
【分类号】：R725.1;R445.2

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