常规及VEGFR2靶向超声造影在结直肠癌肝转移靶向治疗疗效评价中作用研究

发布时间：2018-03-26 05:22

本文选题：靶向超声造影　切入点：结直肠癌　出处：《中国超声医学杂志》2017年09期

【摘要】：目的比较常规超声造影与靶向超声造影定量参数在结直肠癌肝转移靶向治疗疗效评价中的作用。方法建立结直肠癌肝转移裸鼠动物模型并制备VEGFR2靶向造影微泡。30只荷瘤鼠随机分为治疗组及对照组。在治疗前及治疗后7d时进行常规及靶向超声造影检查并得出以下定量参数:达峰时间(TTP)、峰值强度(PI)、曲线上升及下降斜率。同时计算爆破前后PI差值(ΔPI)以及治疗前ΔPI与治疗后ΔPI的差值(ΔΔPI)。比较治疗组与对照组间所有定量参数的差别。结果治疗后7d常规超声造影治疗组仅爆破前PI和爆破后PI显著低于对照组;而在VEGFR2靶向超声造影中,治疗组爆破前PI,爆破后PI、ΔPI及ΔΔPI均显著低于对照组。结论靶向超声造影较常规超声造影能更好地判断结直肠癌肝转移靶向治疗疗效。
[Abstract]:Objective to compare the effects of quantitative parameters of conventional contrast-enhanced contrast-enhanced ultrasound (CEUs) and targeted contrast-enhanced ultrasound on the therapeutic efficacy of liver metastasis in colorectal cancer. Methods the nude mice model of liver metastasis from colorectal cancer was established and VEGFR2 targeted contrast enhanced microbubbles .30 were prepared. The tumor-bearing mice were randomly divided into treatment group and control group. Routine and targeted contrast-enhanced ultrasonography was performed before treatment and 7 days after treatment, and the following quantitative parameters were obtained: peak time, peak intensity, peak intensity, up and down slope of the curve. Pi difference before and after blasting (螖 Pi) and before and after treatment (螖螖 Pi) were calculated. The difference of all quantitative parameters between the treatment group and the control group was compared. Pi was significantly lower than that of control group. However, in the contrast group, the VEGFR2 before blasting, Pi, 螖 Pi and 螖螖 Pi after blasting in the treatment group were significantly lower than those in the control group. Conclusion the targeted contrast-enhanced contrast-enhanced ultrasound is more effective than conventional contrast-enhanced ultrasound in evaluating the therapeutic effect of liver metastasis in colorectal cancer.
【作者单位】：广西桂林医学院第二附属医院乳甲外科超声室;
【分类号】：R445.1;R735.34

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