尿毒症不宁腿患者静息态脑功能磁共振局部一致性研究

发布时间：2018-03-29 04:02

本文选题：功能磁共振成像　切入点：尿毒症不宁腿　出处：《西安交通大学学报(医学版)》2017年04期

【摘要】：目的采用静息态功能磁共振成像评价尿毒症不宁腿(uremic restless legs syndrome,URLS)患者脑部自发神经活动的改变,并进行相关性分析,为URLS神经机制的探索提供客观依据。方法对26例URLS患者和25例健康志愿者(对照组)进行静息态功能磁共振扫描,对患者组进行临床资料收集,计算两组的大脑局部一致性(ReHo)改变,并进行统计学分析。结果与对照组比较,患者组存在情绪心理的异常,而且患者组双侧辅助运动区、双侧丘脑、左侧岛叶、左侧海马ReHo值较对照组均增高(P均0.05),前扣带回、双侧中央后回、右侧杏仁核ReHo值较对照组均减低(P均0.05);患者组RLS严重程度评分与透析龄(r=0.57,P=0.002)、甲状旁腺激素(r=0.419,P=0.033)、BAI(r=0.528,P=0.006)、BDI(r=0.567,P=0.003)呈正相关。结论 URLS患者症状严重程度与透析龄、甲状旁腺激素、焦虑、抑郁等因素相关;URLS患者感觉运动脑区神经元活动一致性存在异常,这种异常对解释维持性透析患者出现不宁腿症状提供了客观的影像学诊断依据。
[Abstract]:Objective to evaluate the changes of brain spontaneous nerve activity in uremic restless legs syndromes (URLs) patients with uremia by resting functional magnetic resonance imaging (fMRI). Methods 26 patients with URLS and 25 healthy volunteers (control group) were examined by resting functional magnetic resonance imaging (fMRI) and the clinical data were collected. Results compared with the control group, the patients had abnormal mood and psychology, and the patients had bilateral auxiliary motor area, bilateral thalamus, left insular lobe. The ReHo of left hippocampus was higher than that of control group (P < 0.05), anterior cingulate gyrus and bilateral posterior central gyrus. The ReHo of the right amygdala was significantly lower than that of the control group (P < 0.05), the severity of RLS in the patients was positively correlated with the age of dialysis, the severity of RLS was positively correlated with the age of dialysis, the level of parathyroid hormone was 0.419, and the level of parathyroid hormone was 0.528 and 0.567P0.003.Conclusion there is a positive correlation between the severity of symptoms of URLS patients and the age of dialysis, parathyroid hormone, anxiety, anxiety, etc. The abnormality of neuronal activity in sensorimotor brain region in patients with depression and other related factors provides an objective imaging diagnostic basis for explaining restless leg symptoms in maintenance dialysis patients.
【作者单位】：西安交通大学第一附属医院影像科;陕西省核工业二一五医院医学影像科;
【基金】：国家自然科学基金面上项目(No.81371530)~~
【分类号】：R445.2;R692.5

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