重组人表皮生长因子凝胶联合中药治疗放射性口腔黏膜炎的疗效观察

发布时间：2018-03-31 16:06

本文选题：放射性口腔黏膜炎　切入点：头颈部肿瘤　出处：《广东医学》2017年20期

【摘要】：目的观察重组人表皮生长因子凝胶联合中药治疗放射性口腔黏膜炎的疗效,为临床寻找一种安全、有效、经济的治疗方案。方法将106例头颈部恶性肿瘤患者随机分为对照组(53例)和观察组(53例)。对照组仅采用对症治疗,观察组在常规对症治疗基础上,从放疗开始应用重组人表皮生长因子凝胶和自制中药,至患者口腔黏膜损伤恢复正常。采用连续放疗,每次1.82~2.18 Gy,每日1次,每周5次,放疗总剂量DT=60~71.96 Gy,放疗方式为三维适形放疗或者调强放疗。结果观察组较对照组放射性口腔黏膜炎发生时间晚、恢复时间短,两者比较差异均有统计学意义(P0.05)。两组中重度放射性口腔黏膜炎发生率分别为观察组60.4%、对照组94.4%,两组间差异有统计学意义(P0.05)。观察组与对照组平均放疗时间分别为(48.61±3.57)d和(57.21±2.76)d,差异有统计学意义(P0.05)。结论重组人表皮生长因子凝胶联合中药能明显减轻发生放射性口腔黏膜炎患者的症状,保证了放疗按时完成,可广泛应用于临床。
[Abstract]:Objective to observe the efficacy of recombinant human epidermal growth factor gel combined with traditional Chinese medicine in the treatment of radiation oral mucositis. Methods 106 patients with malignant tumor of head and neck were randomly divided into control group (n = 53) and observation group (n = 53). From the beginning of radiotherapy, the recombinant human epidermal growth factor gel and traditional Chinese medicine were used until the oral mucosal injury returned to normal. The patients were treated with continuous radiotherapy at 1.82 ~ 2.18 Gy, once a day, 5 times a week. The total dose of radiotherapy was DT=60~71.96 Gy. the radiotherapy mode was three dimensional conformal radiotherapy or intensity modulated radiotherapy. Results the time of radiation oral mucositis in the observation group was later than that in the control group, and the recovery time was shorter than that in the control group. The incidence of moderate and severe radiation oral mucositis in the two groups was 60.4 in the observation group and 94.4 in the control group. The difference between the two groups was statistically significant (P 0.05). The average radiotherapy time of the observation group and the control group was 48.61 卤3.57 days, respectively. The difference was statistically significant (P 0.05). Conclusion Recombinant human epidermal growth factor gel combined with Chinese herbal medicine can obviously alleviate the symptoms of patients with radiation oral mucositis. It ensures that radiotherapy is completed on time and can be widely used in clinic.
【作者单位】：承德医学院附属医院肿瘤科;承德医学院附属医院耳鼻喉科;
【分类号】：R730.55

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