乳腺X线图像纹理特征预测乳腺癌腋窝淋巴结转移

发布时间：2018-04-02 13:00

本文选题：乳腺肿瘤　切入点：淋巴结转移　出处：《中国医学影像技术》2017年12期

【摘要】：目的探讨乳腺X线图像纹理特征预测乳腺癌腋窝淋巴结转移的价值。方法回顾性分析171例病理证实为非特殊类型浸润性乳腺癌患者的X线及临床资料。所有患者均接受腋窝淋巴结清扫手术,并根据手术及病理结果将患者分为腋窝淋巴结转移组和非转移组。分析患者的X线头尾位图像纹理特征,应用灰度直方图及灰度共生矩阵纹理分析方法测定均值、标准偏差、偏度、峰度、方差、能量、熵、自相关、惯量、逆差距和反差等11个纹理参数。结果 171例患者中淋巴结转移组96例,非转移组75例。X线检出腋窝淋巴结阴性119例,阳性52例,其诊断腋窝淋巴结转移的敏感度和特异度分别为48.96%(47/96)和93.33%(70/75)。X线图像纹理分析结果显示腋窝淋巴结转移组能量、熵、逆差距、自相关值均高于非转移组,惯量、反差值均低于非转移组(P均0.05);其余纹理特征参数值两组间差异无统计学意义(P均0.05)。纹理参数值能量、熵、惯量、逆差距、自相关和反差诊断腋窝淋巴结转移的ROC曲线下面积(AUC)值分别为0.610、0.610、0.374、0.599、0.612和0.421(P均0.05)。乳腺X线检查、纹理特征及X线联合纹理特征诊断腋窝淋巴结转移的AUC值分别为0.711、0.676和0.787(P均0.05);纹理特征、乳腺X线联合纹理特征诊断腋窝淋巴结转移的敏感度分别为62.5%和64.6%,特异度分别为66.7%和82.7%。结论乳腺X线图像纹理参数对腋窝淋巴结转移有一定的预测作用,且乳腺X线联合纹理特征可提高对腋窝淋巴结转移的诊断效能。
[Abstract]:Objective to evaluate the value of mammographic texture features in predicting axillary lymph node metastasis of breast cancer.Methods the X-ray and clinical data of 171 cases of non-special invasive breast cancer confirmed by pathology were retrospectively analyzed.All patients underwent axillary lymph node dissection and were divided into axillary lymph node metastasis group and non-metastasis group according to the surgical and pathological results.The texture features of the patients were analyzed. The mean value, standard deviation, deviation, kurtosis, variance, energy, entropy, autocorrelation, inertia were measured by gray histogram and gray co-occurrence matrix texture analysis.Inverse disparity and contrast are 11 texture parameters.Results among 171 cases, 96 cases were lymph node metastasis group, 75 cases were non-metastasis group, 119 cases were axillary lymph node negative, 52 cases were positive.The sensitivity and specificity of the diagnosis of axillary lymph node metastasis were 48.96 / 96) and 93.33% 70 / 75 / 75, respectively. The results of texture analysis showed that the energy, entropy, inverse difference and autocorrelation of axillary lymph node metastasis group were higher than those of non-metastasis group.The contrast value was lower than that in the non-transfer group (P < 0.05), while the other texture parameters had no significant difference between the two groups (P < 0.05).The values of energy, entropy, inertia, inverse disparity, autocorrelation and contrast in the ROC curve of texture parameters for diagnosis of axillary lymph node metastasis were 0. 610 ~ 0. 610 ~ 0. 374 ~ 0. 599 ~ 0. 612 and 0. 421 ~ (-1) P respectively.The AUC values of mammography, texture feature and X-ray combined texture feature in diagnosis of axillary lymph node metastasis were 0.7110.676 and 0.787 (P < 0.05), respectively.The sensitivity of mammography combined with texture in the diagnosis of axillary lymph node metastasis was 62.5% and 64.6%, and the specificity was 66.7% and 82.7%, respectively.Conclusion the texture parameters of mammography can predict axillary lymph node metastasis to some extent, and the combination of mammography and texture features can improve the diagnostic efficiency of axillary lymph node metastasis.
【作者单位】：河南省人民医院放射科;河南省神经疾病影像诊断与研究重点实验室;河南省临床大数据分析与服务工程研究中心;
【基金】：国家自然科学基金(81401378)
【分类号】：R730.44;R737.9

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