多b值弥散加权成像与动脉自旋标记评估轻度认知功能障碍海马灌注的对比研究

发布时间：2018-04-13 17:01

本文选题：认知障碍 + 磁共振成像　；参考：《中国临床医学影像杂志》2017年08期

【摘要】：目的 :对比分析多b值弥散加权成像(MB-DWI)与动脉自旋标记(ASL)在评价轻度认知功能障碍(MCI)患者海马灌注异常中的临床应用价值。方法:依据诊断标准与排除标准,选择MCI患者(MCI组)和认知功能正常的老年人(NC组)各20例,进行常规MRI平扫、MRA、ASL以及MB-DWI扫描,根据ASL-CBF图测量双侧海马最大rCBF_(ASL)值,并测量相应区域MBDWI与灌注相关参数fast ADC-mono、fraction of fast ADC-mono、fast ADC-bi、fraction of fast ADC-bi值,对MCI组和NC组分别进行相应参数的组间统计学差异分析和Pearson相关性分析。结果:MCI组双侧海马rCBF_(ASL)值较NC组降低(P0.05);MCI组双侧海马fast ADC-mono、fraction of fast ADC-mono、fraction of fast ADC-bi值与NC组的比较差异有统计学意义(P0.05),双侧海马fast ADC-bi值较NC组减低,差异无统计学意义(P0.05);除fast ADC-bi值外,MCI组fast ADC-mono、fraction of fast ADC-mono、fraction of fast ADC-bi值与r CBFASL的相关性具有统计学意义(P0.05)。结论:MB-DWI和ASL在检出MCI患者海马的灌注改变方面具有一致性,可用于评估MCI患者灌注改变,有利于指导临床。
[Abstract]:Objective: to compare and analyze the clinical value of MB-DWI and ASL in evaluating hippocampal perfusion abnormalities in patients with mild cognitive impairment (MCI).Methods: according to the diagnostic criteria and exclusion criteria, 20 MCI patients with MCI) and 20 elderly patients with normal cognitive function (NC group) were examined by conventional MRI plain scan and MB-DWI scanning. The maximum rCBFStax ASL value of bilateral hippocampus was measured according to ASL-CBF images.The corresponding regional MBDWI and perfusion related parameters fast ADC-monofraction of fast ADC-Monodo fast ADC-ADC-Monodo fractionof fast ADC-bi were measured. The statistical difference analysis and Pearson correlation analysis of the corresponding parameters between MCI group and NC group were carried out.Results compared with NC group, the value of fast ADC-bi in bilateral hippocampus of MCI group was significantly lower than that in NC group (P 0.05), and the value of fast ADC-bi in bilateral hippocampus was lower than that in NC group (P 0.05).There was no significant difference (P 0.05), except for fast ADC-bi, the correlation between the value of fast ADC-monochrome fractionation of fast ADC-monotaxa fractionation of fast ADC-bi and r CBFASL was statistically significant (P 0.05).ConclusionTwo MB-DWI and ASL are consistent in detecting the changes of hippocampal perfusion in patients with MCI, which can be used to evaluate the changes of perfusion in MCI patients and to guide clinical practice.
【作者单位】：泰山医学院;山东大学附属千佛山医院影像科;
【基金】：山东省科技发展计划项目(2009GG10002024) 山东省医药卫生科技发展计划项目(2009HW075)
【分类号】：R445.2;R749.1

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