1009例婴幼儿先天性心脏病危险因素的病例对照研究

发布时间：2018-04-23 19:51

  本文选题：婴儿 + 心脏病　； 参考：《中华疾病控制杂志》2016年11期

【摘要】：目的探讨母亲围孕期危险因素暴露与婴幼儿先天性心脏病的发病风险。方法病例选择2012年3月1日~2013年10月1日在西京医院经超声心动图检查确诊为先天性心脏病的婴幼儿,对照选择为同期做超声心动图未发生先天性心脏病的婴幼儿。对病例组和对照组父母亲一般情况、母亲孕期环境因素暴露情况进行问卷调查。结果 435例先天性心脏病的婴幼儿和574例未发生先天性心脏病的婴幼儿的父母亲基本情况及母亲围孕期相关危险因素分析结果显示,母亲怀孕早期服用药物(OR=4.65,95%CI:2.84~7.66)、病毒感染(OR=3.15,95%CI:1.66~6.01)、房屋装修(OR=1.87,95%CI:1.24~2.80)、染发烫发(OR=2.18,95%CI:1.37~3.49)、父母工作环境污染暴露(OR=2.88,95%CI:1.86~4.47)均是造成心血管畸形的独立危险因素。随着暴露因素的增多,先天性心脏病发病的危险程度显著增加。当孕期同时受到3种或3种以上危险因素的暴露时,婴幼儿罹患先天性心脏病的危险性是单因素暴露的16.35倍。结论婴幼儿先天性心脏病的发病与围孕期危险因素的暴露存在相关性。
[Abstract]:Objective to explore the risk of maternal exposure during pregnancy and congenital heart disease in infants. Methods infants with congenital heart disease were selected from March 1, 2012 to October 1, 2013 in Xijing Hospital. The general condition of parents and maternal exposure to environmental factors during pregnancy were investigated in case group and control group. Results the parents' basic condition of 435 infants with congenital heart disease and 574 infants without congenital heart disease and the maternal risk factors during pregnancy were analyzed. In the early pregnancy, the mother took the drug ORO 4.65 / 95 CI: 2.847.66, the virus infected OR3.1595 / CI 1.66: 6.01, the house decoration 1.8795 CIW 1.24795 CIW1.242.80, the hair perm 2.1895 hair perm 1.373.49, the parents exposed to occupational pollution, OR2.88-95% CI1.864.47) were all independent risk factors for cardiovascular malformations. With the increase of exposure factors, the risk of congenital heart disease increased significantly. When exposed to three or more risk factors simultaneously during pregnancy, infants were 16.35 times more likely to develop congenital heart disease. Conclusion the incidence of congenital heart disease in infants is associated with exposure to risk factors during pregnancy.
【作者单位】： 陕西省西北妇女儿童医院医学超声中心;第四军医大学军事预防医学系流行病学教研室;
【分类号】：R725.4;R540.45
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