钆对比剂对腹部实性脏器体素内不相干运动磁共振成像的影响

发布时间：2018-05-19 19:41

本文选题：肝肿瘤 + 磁共振成像　；参考：《中国医学影像学杂志》2015年02期

【摘要】：目的探讨钆对比剂对腹部实性脏器体素内不相干运动(IVIM)MRI图像质量及其参数值的影响,寻找腹部IVIM序列扫描的合适时机。资料与方法 20例患者分别于对比剂注射前后行相同腹部IVIM扫描,测量并计算b=50、300、800 s/mm2扩散加权成像(DWI)图像上肝脏、脾脏、胰腺、肾脏的信噪比(SNR)以及肝细胞癌(HCC)的SNR以及对比噪声比(CNR),并测量肝脏、脾脏、肾脏及HCC的表观扩散系数(ADC)值及IVIM参数(D值、D*值、f值),对各测量值增强扫描前后的差异进行比较。结果增强扫描后b=50 s/mm2肝脏的SNR较增强前明显下降(t=2.397,P0.05)。b=300 s/mm2 HCC的CNR显著增高(t=-3.380,P0.01)。肾脏各b值的SNR均较增强扫描前显著下降(Z=-2.675~-2.201,P0.05);而脾脏、胰腺及HCC各b值的SNR与增强扫描前的差异均无统计学意义(t或Z=-1.324~1.104,P0.05)。增强扫描后仅肾脏的ADC值、D值下降,差异有统计学意义(tADC=3.569,P0.01;ZD=-3.053,P0.01),而肝脏、脾脏及HCC的各参数值增强扫描前后差异均无统计学意义(t=-1.102~1.689,P0.05)。结论注射钆对比剂可降低肝脏低b值和肾脏各b值DWI的SNR,使中等b值肝脏病变的CNR增高,而不影响脾脏、胰腺和肝脏病变的SNR。钆对比剂亦可降低肾脏的ADC值、D值,而对肝脏及其病变、脾脏的DWI及IVIM参数无影响。
[Abstract]:Objective to investigate the effect of gadolinium contrast agent on the image quality and parameters of abdominal solid visceral incoherent motif (IVIMI), and to find a suitable time for abdominal IVIM sequence scanning. Materials and methods 20 patients underwent the same abdominal IVIM scan before and after injection of contrast medium, and measured and calculated the liver, spleen and pancreas on the image of BF50300800 s/mm2 diffusion weighted imaging (DWI). The SNR and contrast noise ratio of kidney and hepatocellular carcinoma were measured. The apparent diffusivity of liver, spleen, kidney and HCC were measured, and the D value and D value of IVIM were also measured. The difference before and after enhanced scanning was compared. Results the SNR of liver at 50 s/mm2 after enhanced scanning was significantly lower than that before enhancement. The CNR of P0.05, BX 300 s/mm2 HCC was significantly higher than that of P0.01-3.380 s/mm2 HCC. The SNR of each b value in kidney was significantly lower than that before enhanced scan. However, the SNR of spleen, pancreas and HCC were not significantly different from those before enhanced scan, and there was no significant difference in SNR of spleen, pancreas and HCC between before and after enhanced scan (P 0.05). Only the ADC value of kidney decreased after enhanced scanning, and the difference was statistically significant. There was no significant difference in the parameters of liver, spleen and HCC before and after the enhanced scanning, and there was no significant difference between the parameters of liver, spleen and HCC before and after enhanced scanning. Conclusion injection of gadolinium contrast agent can decrease the DWI of liver and kidney, and increase the CNR of liver lesion with moderate b value, but not affect the SNR of spleen, pancreas and liver. Gadolinium contrast agent also decreased the ADC value and D value of kidney, but had no effect on DWI and IVIM parameters of liver and spleen.
【作者单位】：南方医科大学;广东省人民医院(广东省医学科学院)放射科;
【基金】：国家自然科学基金项目(81271654);国家自然科学基金项目(81271569) 广州市科技支撑项目(2010J-E481)
【分类号】：R445.2

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