CEUS定量分析鉴别诊断乳腺肿瘤的价值及其与微血管密度的相关性分析

发布时间：2018-05-20 07:30

本文选题：乳腺肿瘤 + 超声造影　；参考：《中国医学影像技术》2015年10期

【摘要】：目的采用CEUS时间-强度曲线(TICs)各参数鉴别良恶性肿瘤的价值及其与微血管密度(MVD)间的关系。方法纳入获得病理诊断的患者79例,其中良性病变56例,恶性病变23例。手术病理标本切片行免疫组织化学染色检测MVD。采用SonoLiver软件定量分析各参数与MVD关系。结果乳腺病灶TICs的各参数在良恶性肿瘤之间比较差异无统计学意义(P0.05);乳腺病灶的IMAX及QOF明显高于乳腺实质,而且RT、TTP、mTT均较乳腺实质短(P0.05)。恶性病灶MVD数目为(173.16±64.67)个/mm2,良性病灶MVD数目为(149.01±35.16)个/mm2,差异有统计学意义(P=0.04)。TICs各参数只有IMAX与MVD相关(r=0.229,P=0.048)。结论乳腺病变CEUS定量参数的IMAX与MVD存在正相关,通过定量分析的峰值强度参数可以初步评估乳腺肿瘤内微血管密度。
[Abstract]:Objective to identify the value of CEUS time intensity curve (TICs) in differentiating benign and malignant tumors and its relationship with microvessel density (MVD). Methods 79 cases of pathological diagnosis were included, including 56 cases of benign lesions and 23 cases of malignant lesions. Immunohistochemical staining was used to detect MVD. The relationship between parameters and MVD was quantitatively analyzed by SonoLiver software. Results there was no significant difference in the parameters of TICs between benign and malignant tumors (P 0.05), and the IMAX and QOF of breast lesions were significantly higher than those of breast parenchyma, and the IMAX and QOF of breast lesions were shorter than those of breast parenchyma (P 0.05). The number of MVD in malignant lesions was 173.16 卤64.67 / mm2, and the number of MVD in benign lesions was 149.01 卤35.16 / mm2. The difference was statistically significant (P < 0.01). Conclusion there is a positive correlation between IMAX and MVD in the quantitative parameters of CEUS in breast lesions, and the microvessel density in breast tumors can be preliminarily evaluated by the peak intensity parameters of quantitative analysis.
【作者单位】：中山大学附属第一医院超声波科超声诊断与介入超声研究所;
【分类号】：R737.9;R445.1

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