右侧颞叶癫痫患者视空间工作记忆的静息态功能磁共振研究

发布时间：2018-05-31 19:22

本文选题：颞叶癫痫 + 静息态功能磁共振　；参考：《中风与神经疾病杂志》2013年12期

【摘要】：目的分析右侧颞叶癫痫(right-temporal lobe epilepsy,rTLE)患者静息态视空间工作记忆(visuospatial working memory,vSWM)相关脑网络的激活特点,探讨患者VSWM损害的脑功能机制。方法对15例rTLE患者和16例健康受试行静息态功能磁共振(RS-fMRI)扫描,运用基于稳定的群组独立成分分析(mutiple independent component analysis,MICA)方法提取VSWM相关脑网络,并对其空间分布及功能连接(functional connectivity,FC)行组间比较。结果 rTLE组与健康组静息态VSWM相关脑网络的激活分布大致相同,主要位于右背外侧前额叶、右侧顶叶、左顶下小叶及部分左小脑后叶(Pα0.05,alphasim校正);rTLE组静息态VSWM相关脑网络内FC在右侧额上回(BA8区)、右额中回及右腹内侧前额叶较健康组减弱,而在右额上回(BA11区)、右顶上小叶及左小脑后叶较健康组增强(Pα0.05,alphasim校正)。结论 rTLE患者存在静息态VSWM相关脑网络的异常,其可能通过增加同侧网络内的功能连接对记忆功能进行代偿。
[Abstract]:Objective to investigate the activation characteristics of brain network associated with resting visual spatial working memory (VSWM) in patients with right-temporal lobe epilepsyrTLE. and to explore the mechanism of VSWM damage in patients with right temporal lobe epilepsy. Methods Fifteen patients with rTLE and 16 healthy subjects were examined by resting functional magnetic resonance imaging (FMR). VSWM related brain networks were extracted by using a stable cohort independent component analysis (ICA) method. The spatial distribution and functional connectivity of FCC were compared. Results the activation distribution of resting VSWM related brain network in rTLE group and healthy group was approximately the same, mainly located in the right dorsolateral prefrontal lobe and right parietal lobe. In the left inferior parietal lobule and part of the left posterior lobe of the left cerebellum, P 伪 0.05 alphasim corrected the resting VSWM related brain network of the rTLE group. FC in the right superior frontal gyrus in the BA8 area, the right middle frontal gyrus and the right ventromedial prefrontal lobe were weaker than those in the healthy group. In the right superior frontal gyrus BA11, the right superior parietal lobules and the left cerebellar posterior lobe enhanced P 伪 0.05 alphasim correction. Conclusion there is an abnormality of resting VSWM related brain network in patients with rTLE, which may compensate for memory function by increasing functional connections in ipsilateral network.
【作者单位】：广西医科大学第一附属医院神经内科;广西医科大学第一附属医院放射科;
【基金】：广西自然科学基金面上项目(2011GXNSFA018263)
【分类号】：R742.1

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