磁共振波谱成像定量腰椎骨髓脂肪短中期的可重复性研究

发布时间：2018-06-04 01:07

本文选题：磁共振波谱学 + 骨髓脂肪　；参考：《中国全科医学》2017年12期

【摘要】：目的评价磁共振波谱成像(MRS)定量腰椎骨髓脂肪短、中期的可重复性。方法选择2015年3—6月在温州市第七人民医院和温州市中医院健康体检中心体检的符合入选标准的健康女性(28.9~48.6岁)受检者30位,基线(即研究开始时)及6个月时测定受检者血25羟维生素D、骨钙素、β-胶原降解产物及雌二醇。于基线、6周及6个月时分别行3次MRS扫描,测定腰3椎体骨髓脂肪分数(FF)。由2位评定者独立测定FF,计算组内相关系数(ICC),评价不同时间点(短期和中期)MRS测定FF的精确性。结果共22位受检者完成研究。评定者间与评定者内在基线、6周及6个月时测定FF的ICC为0.931~0.988。Bland-Altman法分析显示,评定者间、评定者内测定FF的差值均落于95%可信区间内。短期和中期MRS测定FF的ICC为0.856~0.944,变异系数为2.45%~4.72%。结论短、中期MRS测定腰椎骨髓脂肪含量具有良好的可重复性。
[Abstract]:Objective to evaluate the reproducibility of lumbar bone marrow fat short and middle stage by magnetic resonance spectroscopy imaging (MRS). Methods A total of 30 healthy women, aged 28. 9 or 48. 6 years old, who were examined in Wenzhou Seventh people's Hospital and Wenzhou traditional Chinese Medicine Hospital from March to June 2015, were selected. Blood 25 hydroxyvitamin D, osteocalcin, 尾-collagen degradation products and estradiol were measured at baseline (at the beginning of the study) and at 6 months. The bone marrow fat fraction of lumbar 3 vertebrae was measured by MRS scan at baseline 6 weeks and 6 months. FFs were measured independently by two evaluators and the correlation coefficients were calculated to evaluate the accuracy of FF at different time points (short and medium term). Results A total of 22 subjects completed the study. The ICC analysis of FF between the evaluator and the internal baseline at 6 weeks and 6 months showed that the difference of FF between the evaluators and the evaluators was within 95% confidence interval. The ICC of FF determined by MRS in short and medium term was 0.856 ~ 0.944, and the coefficient of variation was 2.45 ~ 4.72. Conclusion MRS has good reproducibility in measuring bone marrow fat content of lumbar vertebrae.
【作者单位】：浙江省温州市第七人民医院放射科;浙江省温州市第七人民医院特检科;浙江省温州市中医院;
【分类号】：R445.2

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