缺血性脑白质病额顶叶白质的扩散峰度表现

发布时间：2018-06-08 14:52

本文选题：脑白质病 + 进行性多灶性　；参考：《中国医学影像学杂志》2016年07期

【摘要】：目的探讨缺血性脑白质病的额顶叶脑白质扩散峰度表现,并评价高级别Fazekas的病灶特点。资料与方法回顾性分析经临床确诊为缺血性脑白质病的46例患者的扩散峰度成像(DKI)资料,Fazekas 0~3级,比较其额顶叶正常脑白质及病灶的平均扩散峰度(MK)、平均扩散系数(MD)、各向异性分数(FA)、峰度各向异性分数(FA_k)、轴向扩散峰度(Ka)、径向扩散峰度(Kr)、轴向扩散系数(Da)、径向扩散系数(Dr)加权值的差异。结果 1病灶加权MD、Ka、Dr与Fazekas分级呈正相关(r=0.795、0.863、0.668,P0.05),加权MK、Kr、Da与Fazekas分级呈负相关(r=-0.616、-0.682、-0.807,P0.05);2额顶叶正常白质各DKI参数MK、MD、FA、FAk、Ka、Kr、Da、Dr加权值与Fazekas分级无明显相关性(P0.05)。3 4个Fazekas分级组的额顶叶正常白质各参数MK、MD、FA、FA_k、Ka、Kr、Da、Dr比较,差异有统计学意义(P0.05),其中Fazekas 0级与Fazekas 3级组各参数间差异均有统计学意义(P0.05)。4 4个Fazekas分级组的额顶叶病灶MK、MD、FA、FA_k、Ka、Kr、Da、Dr的加权值差异均有统计学意义(P0.05)。5 Fazekas 3组额顶叶病灶的加权MK值与FA值、加权Kr与FA值呈正相关(r=0.69、0.72,P0.05),加权Kr值与Dr值呈负相关(r=-0.95,P0.05)。结论 DKI能早期反映额顶叶正常白质扩散峰度变化的差异,能先于T2液体衰减反转恢复序列敏感地探测出缺血性脑白质病额顶叶白质病变;DKI可以发现缺血性脑白质病额顶叶白质扩散峰度的变化特点。
[Abstract]:Objective to investigate the diffusion kurtosis of frontal and parietal white matter in ischemic white matter disease and to evaluate the characteristics of high grade Fazekas. Materials and methods the DKI data of 46 patients with ischemic leukoencephalopathy were retrospectively analyzed. The mean diffusion kurtosis of normal white matter and lesions in the frontal and parietal lobes were compared. The mean diffusion coefficients were MDI, anisotropic fraction, kurtosis, axial diffusion kurtosis, radial diffusion kurtosis, axial diffusion coefficient, radial diffusion kurtosis, radial diffusion coefficient, radial diffusion kurtosis, radial diffusion coefficient. The difference in the weighted value of the coefficient Dr. Results (1) there was a positive correlation between the weighted MDKI and the Fazekas grade. There was no significant correlation between the weighted MKU KrDa and the Fazekas grade. There was a negative correlation between the weighted MKU KrDa and the Fazekas grade. There was a negative correlation between MKI and Fazekas grade. The DKI parameters of the normal white matter of the parietal lobe were not significantly correlated with those of the Fazekas classification group (P 0.05.3). There were significant differences in the parameters between Fazekas grade 0 and Fazekas grade 3. There were significant differences in the weighted MK value and FA value of the frontal and parietal lobe lesions in the Fazekas grade 0 and Fazekas grade 3 groups. The weighted MK value and FA value of the frontal and parietal lobe lesions in the Fazekas grade group were significantly higher than those in the Fazekas grade 3 group (P 0.05.5 Fazekas grade 3), and there were significant differences in the weighted MK values and FA values of the frontal and parietal lobe lesions in the Fazekas grade 0 and Fazekas grade 3 groups. There was a positive correlation between the weighted Kr and the FA value, and a negative correlation between the weighted Kr value and the Dr value. Conclusion DKI can reflect the difference of diffusion kurtosis of normal white matter in frontal parietal lobe early. DKI can detect the change of diffusion kurtosis of white matter in frontal parietal white matter of ischemic white matter disease before T2 fluid attenuated inversion recovery sequence.
【作者单位】：福建医科大学附属泉州第一医院影像科;福建省石狮市医院影像科;
【基金】：泉州市重点科技项目(2014Z39)
【分类号】：R742;R445.2

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