外伤性脑损伤脑桥快速波谱成像研究

发布时间：2018-06-08 16:25

本文选题：颅脑外伤 + 快速磁共振波谱成像　；参考：《临床放射学杂志》2015年02期

【摘要】：目的探讨颅脑外伤(TBI)所致脑桥代谢物变化规律及其与预后的关系。方法对34例TBI患者行快速波谱成像(TSI),获得NAA/Cr、Cho/Cr、Cho/NAA值,并与16例正常志愿者(对照组)进行对比。将TBI组根据格拉斯哥预后评分分为预后良好、中等、差3组,比较不同组间代谢物水平差别。结果 TBI组34例脑桥NAA/Cr、Cho/Cr、Cho/NAA均值分别为2.51±0.73、2.56±0.67、1.05±0.29;对照组16例NAA/Cr、Cho/Cr、Cho/NAA均值分别为2.70±0.37、1.92±0.09、0.72±0.08。两组间NAA/Cr均值差异无统计学意义(P=0.235),两组间Cho/Cr、Cho/NAA均值差异有显著统计学意义(P值均=0.000)。NAA/Cr在预后差组(2.15±0.56)与预后中等组(2.73±0.58)之间、预后差与预后良好组(2.98±0.90)间差异有统计学意义(P值分别为0.036、0.007)。Cho/Cr 3组之间差异无统计学意义。Cho/NAA在预后差组(1.22±0.31)与预后良好组(0.80±0.15)之间差异有统计学意义(P=0.001)。结论 TSI适合TBI脑桥MRS检测,TBI患者脑桥Cho/Cr和Cho/NAA较正常人升高,而NAA/Cr和Cho/NAA比值对TBI预后判断较有意义。
[Abstract]:Objective to investigate the changes of brain pons metabolites induced by TBI and their relationship with prognosis. Methods 34 patients with TBI underwent rapid spectral imaging with TSII to obtain NAA / Cro / CrChoP / NAA value, and compared with 16 normal volunteers (control group). According to Glasgow prognosis score, TBI group was divided into 3 groups with good prognosis, moderate prognosis and poor prognosis. Results in TBI group, the mean values of NAA / CrChoP / CrCho-NAA were 2.51 卤0.73 卤0.67 卤1.05 卤0.29 and 2.70 卤0.37 卤1.92 卤0.090.72 卤0.08 in the control group and 16 cases in the control group, respectively2.51 卤0.73 卤0.67 卤0.67 卤1.92 卤0.090.72 卤0.08, respectively, and the mean values of NAA / NAA in the control group were 2.70 卤0.37 卤1.92 卤0.090.72 卤0.08, respectively. There was no significant difference in the mean value of NAA / Cr between the two groups. There was significant difference in the mean value of NAA between the two groups (P < 0.000). NAA / Cr was between 2.15 卤0.56 in the poor prognosis group and 2.73 卤0.58 in the middle prognosis group (P < 0.05), and there was no significant difference between the two groups in the mean value of NAA / Cr in the poor prognosis group (2.15 卤0.56) and the moderate group in the prognosis group (2.73 卤0.58). The difference between poor prognosis group and good prognosis group (2.98 卤0.90) was statistically significant (P = 0.036, P = 0.007, P < 0.05). There was no significant difference between the two groups (P = 0.80 卤0.15). There was no significant difference between the poor prognosis group (1.22 卤0.31) and the good prognosis group (0.80 卤0.15). Conclusion TSI is suitable for the detection of pons in patients with TBI by Mrs, and the ratio of NAA / Cr and Cho/ NAA is higher than that of normal subjects, and the ratio of NAA / Cr and Cho/ NAA is more significant in predicting the prognosis of TBI.
【作者单位】：广东省中山市人民医院MR室;
【基金】：广东省医学科研基金资助项目(编号:A2012817) 中山市科技计划项目(编号:20122A081)
【分类号】：R651.15;R445.2

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