额叶肿瘤静息态功能磁共振比率低频振幅的研究

发布时间：2018-06-12 11:38

本文选题：静息态 + 功能磁共振　；参考：《生物医学工程研究》2015年01期

【摘要】：采用静息态下功能磁共振成像(f MRI)比率低频振幅(f ALFF)测量技术,从能量的角度对额叶肿瘤患者与正常对照组进行比较分析,探讨额叶肿瘤患者认知功能失调的病理机制。本研究分别对14例额叶肿瘤患者和14例性别、年龄及受教育程度均相匹配的健康对照组进行静息态f MRI扫描,用f ALFF算法进行比较分析。结果显示额叶肿瘤组同正常对照组相比,额叶肿瘤组f ALFF值升高的脑区主要集中在右侧眶额回、右侧颞叶、右侧辅助运动区、左侧海马旁回、左侧后扣带回、左侧内侧和旁扣带及旁中央小叶,f ALFF值降低的脑区主要集中在双侧背外侧额上回、双侧内侧额上回和小脑。研究结果显示在静息态下额叶肿瘤患者的额叶功能活动降低,这与额叶肿瘤部分组织的失活有关,而其余的默认网络区域、辅助运动区和旁中央小叶的活动增强,可能与额叶肿瘤脑认知功能失调及代偿作用有关。
[Abstract]:In order to explore the pathological mechanism of cognitive dysfunction in patients with frontal lobe tumors, the low frequency amplitudes of functional magnetic resonance imaging (MRI) ratio were measured in resting state and compared with those in normal controls from the point of view of energy. In this study, 14 patients with frontal lobe tumor and 14 healthy controls matched with gender, age and education were examined by rest fMRI, and the results were compared with that of fALFF algorithm. The results showed that the increase of f ALFF in frontal lobe tumor group was mainly in the right orbitofrontal gyrus, right temporal lobe, right auxiliary motor area, left para-hippocampal gyrus, left posterior cingulate gyrus. In the left medial and paracentral cingulate bands and in the central lobules of the paraventral lobules, the decrease of f ALFF was mainly in bilateral dorsolateral superior frontal gyrus, bilateral medial superior frontal gyrus and cerebellar gyrus. The results showed that the functional activity of frontal lobe decreased in patients with frontal lobe tumor at rest, which was related to the inactivation of some tissues of frontal lobe tumor, while the rest of the default network area, auxiliary motor area and paracentral lobules were increased. It may be related to cognitive dysfunction and compensatory effect of frontal lobe tumor.
【作者单位】：南京航空航天大学自动化学院;
【基金】：国家自然科学基金资助项目(61075107)
【分类号】：R739.41;R445.2

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