艾滋病合并脑内感染的扩散张量成像初步研究

发布时间：2018-06-17 17:05

本文选题：艾滋病 + 结核　；参考：《中国医学计算机成像杂志》2015年05期

【摘要】：目的:探讨弥散张量成像(DTI)在艾滋病脑内机会感染结核和弓形虫中的初步诊断价值。方法:收集经临床证实艾滋病合并脑内结核患者12例,弓形虫脑病10例,行MRI平扫、DTI和T1WI增强检查,观察病变形态学特征并测量病灶实质区、邻近水肿区及对侧正常区FA值、ADC值,使用单因素方差分析及t检验进行统计学分析。纤维束成像(DTT)观察病灶区纤维束的走形变化。结果:两感染组病灶实质区、水肿区及正常区ADC值及FA值间有显著差异(P0.05),与对侧正常区相比,实质区、水肿区ADC值、FA值均有统计学意义(P0.05),两感染灶实质区与水肿区FA值及结核性病灶实质区与水肿区ADC值均有统计学差异(P0.05)。两组间实质区FA值存在差异(t=-3.082,P0.05)。纤维束成像见部分白质纤维中断、缺失,并伴推压移位。结论:DTI能为临床诊断和鉴别诊断AIDS合并脑内机会性感染的类型提供更多有价值信息。
[Abstract]:Objective: to evaluate the diagnostic value of diffusion Zhang Liang imaging (DTI) in the diagnosis of opportunistic tuberculosis and toxoplasma gondii in patients with AIDS. Methods: 12 cases of AIDS complicated with cerebral tuberculosis and 10 cases of toxoplasma encephalopathy were collected and examined by plain MRI DTI and T 1WI. The morphological features of the lesions were observed and the solid areas of the lesions were measured. The FA value and ADC value of adjacent edema area and contralateral normal area were statistically analyzed by univariate ANOVA and t test. Fiber bundle imaging (DTT) was used to observe the shape of the fibrous bundle in the focus area. Results: there were significant differences in ADC and FA values between the parenchymal, edema and normal areas of the lesions in the two infected groups (P < 0.05), and the parenchymal areas were significantly different from those in the contralateral normal areas. There was significant difference in ADC value and FA value in edema area (P < 0.05), FA value in parenchymal area and edema area (P < 0.05), and ADC value in tuberculous lesion area (P < 0.05). There was significant difference in FA between the two groups. Some white matter fibers were found to be interrupted, missing, and accompanied by pressure shift on bundle imaging. ConclusionTwo-DTI can provide more valuable information for clinical diagnosis and differential diagnosis of AIDS with intracerebral opportunistic infection.
【作者单位】：新疆医科大学第二附属医院影像中心;
【基金】：新疆维吾尔自治区自然科学基金(No.2014211C087) 乌鲁木齐市科学技术计划(No.Y131310011)~~
【分类号】：R445.2;R512.91;R742.9

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