3.0T MR多b值DWI序列评价胰腺癌放疗疗效

发布时间：2018-06-27 06:48

本文选题：扩散磁共振成像 + 胰腺肿瘤　；参考：《中国医学影像技术》2015年04期

【摘要】：目的应用3.0T MR多b值DWI序列评价胰腺癌放疗疗效。方法对24例胰腺癌患者行DWI扫描,b值为0,600,800,1000s/mm2,于AW 4.5工作站利用Functool ADC软件进行处理,记录胰腺癌肿块区、肿块邻近区、肿块远离区ADC值;放疗1个月后再重复上述操作过程;比较胰腺癌患者放疗前后各b值条件下各测量区域ADC值,计算放疗前后胰腺癌肿块区ADC值变化率(rADC)、筛选评价放疗疗效的最佳b值。结果 b值分别取600、800、1000s/mm2时,放疗前肿块区与邻近区ADC值的差异无统计学意义(t=1.75、0.22、0.38,P均0.05),肿块区与肿块远离区ADC值的差异有统计学意义(t=7.19、3.98、3.50,P均0.01);肿块区、肿块邻近区放疗前后ADC值的差异均有统计学意义(肿块区:t=7.94、5.95、6.51,P均0.01;肿块邻近区:t=2.96、6.46、8.83,P均0.01),肿块远离区放疗前后ADC值的差异无统计学意义(t=0.53、1.99、2.02,P均0.05)。b值为600,800,1000s/mm2时的rADC分别为(32.42±1.97)%、(28.44±2.44)%、(30.27±2.03)%。评价放疗疗效最佳b值为600s/mm2。结论 3.0T MR多b值DWI序列评价胰腺癌放疗早期疗效具有重要临床意义。
[Abstract]:Objective to evaluate the radiotherapy effect of pancreatic cancer with 3. 0 T Mr multi-b-value DWI sequence. Methods Twenty-four patients with pancreatic cancer underwent DWI with a DWI value of 600 ~ 800 ~ 1000s / m ~ (-2). The AW 4.5 workstation was treated with Functool ADC software to record the ADC values of the tumor area, adjacent area and distant area of the tumor, and to repeat the above procedure one month after radiotherapy. Before and after radiotherapy, the ADC values of each area were compared, and the change rate of ADC values (rADC) in pancreatic cancer masses were calculated before and after radiotherapy, and the best b value was selected to evaluate the curative effect of radiotherapy. Results there was no significant difference in ADC between the tumor area and the adjacent area before radiotherapy (t = 1.75 卤0.22 0.38, P 0.05), but there was significant difference between the ADC value between the mass area and the distant area of the mass (t = 7.19 卤3.98, P < 0.01), while the ADC value between the mass area and the distant area was significantly higher than that in the adjacent area (P < 0.05), and the ADC value in the mass area was significantly different from that in the distant area (t = 7.19 卤3.98, P < 0.01). There were significant differences in ADC values before and after radiotherapy in the adjacent areas of the mass (t: t 7.945.956.51g P 0.01; in the adjacent areas of the masses: t 2.966.46.68.83P 0.01), but there was no significant difference between the ADC values before and after radiotherapy in the areas away from the mass (t 0.531.99.2.02P 0.05). The values of the ADC were (32.42 卤1.97), (28.44 卤2.44), (30.27 卤2.03), respectively, when the values of the masses were 600,800 (1000s / mm2), (28.44 卤2.44), (30.27 卤2.03), respectively. The ADC values of the tumor adjacent areas were (32.42 卤1.97), (28.44 卤2.44) and (30.27 卤2.03), respectively. The best b value to evaluate the efficacy of radiotherapy was 600s / mm2. Conclusion 3. 0 T Mr multi-b-value DWI sequence is of great clinical significance in evaluating the early therapeutic effect of radiotherapy for pancreatic cancer.
【作者单位】：空军总医院放射科;空军总医院磁共振科;空军总医院放疗科;首都医科大学附属北京康复医院老年康复中心;
【分类号】：R445.2;R735.9

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