下肢局限性硬皮病的临床和磁共振表现特点

发布时间：2018-07-10 14:40

本文选题：局限性硬皮病 + 核磁共振成像　；参考：《中国医学科学院学报》2015年04期

【摘要】：目的探索局限性硬皮病下肢受累患者的临床特点,以及受累下肢的核磁共振成像(MRI)影像表现特点。方法回顾性分析2013年4月至2014年6月在北京协和医院接受下肢MRI检查的局限性硬皮病患者16例。收集患者的一般临床资料、抗核抗体、抗双链DNA抗体和抗可提取性核抗原抗体的实验室检查结果。核磁共振成像检查均为平扫,机器为西门子Skyra 3.0T核磁扫描仪。结果线状硬斑病11例、泛发性硬斑病4例、深在性硬斑病1例。14例患者接受抗核抗体检查,其中4例阳性(28.6%)。10例进行抗双链DNA抗体检查和7例进行抗可提取性核抗原抗体检查的结果均为阴性。最常见的MRI影像表现为皮下脂肪间隔增厚(16例)和肌肉筋膜增厚(11例),既可为T1加权成像低信号、T2快速反转恢复预脉冲/质子加权成像低信号,也可为T1加权成像低信号、T2快速反转恢复预脉冲/质子加权成像高信号。另外,还包括肌间筋膜增厚(3例)、肌肉异常信号(1例)和骨髓异常信号(2例)。结论磁共振检查能提示局限性硬皮病下肢骨骼肌肉受累的范围和程度。
[Abstract]:Objective to explore the clinical features and MRI features of patients with local scleroderma. Methods from April 2013 to June 2014, 16 patients with local scleroderma underwent MRI examination in Peking Union Hospital. The clinical data of the patients were collected, and the results of laboratory examination of antinuclear antibodies, anti-dsDNA antibodies and anti-extractable nuclear antigen antibodies were collected. Magnetic resonance imaging are all plain scan, the machine is Siemens Skyra 3.0 T nuclear magnetic scanner. Results 11 cases of linear scleroplakia, 4 cases of generalized scleroplakia and 1 case of deep scleroplakia were examined with anti-nuclear antibody. Among them, 4 cases (28.6%) were positive, 10 cases were tested for anti-dsDNA antibody, and 7 cases were negative for anti-extractable nuclear antigen antibody. The most common MRI findings were subcutaneous fat septal thickening (16 cases) and myofascial thickening (11 cases). It can also restore prepulse / proton weighted high signal for T 1 weighted low signal / T 2 fast inversion. In addition, myofascial thickening (3 cases), abnormal muscle signal (1 case) and bone marrow abnormal signal (2 cases) were also included. Conclusion MRI can indicate the extent and extent of skeletal muscle involvement in local scleroderma.
【作者单位】：中国医学科学院北京协和医学院北京协和医院放射科;中国医学科学院北京协和医学院北京协和医院皮肤科;中国医学科学院北京协和医学院北京协和医院骨科;
【基金】：卫生公益性行业科研专项项目(201402019)~~
【分类号】：R445.2;R593.25

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