桥脑扩散内生型胶质瘤行为抑制减低患儿静息态功能MRI

发布时间：2018-07-10 16:06

本文选题：桥脑胶质瘤 + 行为支配　；参考：《放射学实践》2017年06期

【摘要】：目的:应用静息态功能磁共振成像(rs-fMRI)探讨桥脑扩散内生型胶质瘤(DIPG)行为抑制减低患儿静息态局部一致性变化情况。方法:对16例DIPG患儿(行为抑制减低组7例,无明显行为抑制减低组9例)和5例年龄、性别及教育程度相匹配的健康志愿者行rs-fMRI,每组分别进行局部一致性(ReHo)分析,运用单因素方差(ANOVA)分析及双样本t检验分别比较3组间及DIPG两组间大脑活动的变化,并对差异脑区的ReHo值与Achenbach儿童行为量表(CBCL)评分进行相关性分析。结果:三组儿童在涉及抑制控制相关脑区上出现了局部活动的显著异常[P0.05,多重比较(AlphaSim)联合簇89个体素],3组相比ReHo值升高的脑区有双侧眶部额中回、左侧梭状回、左侧枕中回、左侧枕上回、右侧缘上回、左侧辅助运动区及双侧罗兰迪克岛盖(bilateral Rolandic operculum)。DIPG两组间,行为抑制减低组ReHo值降低的脑区包括右额上回内侧、右侧缘上回[P0.05,多重比较(AlphaSim)联合簇89个体素]。DIPG组(行为抑制减低组及无行为抑制减低组)中双侧额中回、右额上回内侧、左侧梭状回的ReHo值与CBCL量表评分无显著相关(P0.05),右侧缘上回的ReHo值与CBCL量表评分呈显著正相关(行为抑制减低组r=0.950,P=0.001;无行为抑制减低组r=0.709,P=0.033)。结论:DIPG行为抑制减低患儿出现了与抑制控制相关的脑区功能活动异常,可能由于相关脑区的"低能"、"低效"表现。本研究为脑干病变在脑功能方面的研究开辟了新思路。
[Abstract]:Objective: to investigate the local consistency of resting state with resting functional magnetic resonance imaging (rs-fMRI) in children with reduced behavior inhibition of diffuse pons glioma (DIPG). Methods: 16 children with DIPG (7 children with reduced behavior and 9 without behavior inhibition) and 5 healthy volunteers with matched age, sex and education were treated with rs-f MRI.The local consistency (ReHo) was analyzed in each group. Single factor variance (ANOVA) analysis and double sample t-test were used to compare the changes of brain activity between three groups and two groups, and the correlation between ReHo value of different brain area and Achenbach children's behavior scale (CBCL) score was analyzed. Results: in the three groups, there were significant abnormal local activities in the brain regions involved in inhibition and control [P0.05, multiple comparison (AlphaSim) combined with cluster 89 ontogenin]. In the three groups, there were bilateral orbital middle frontal gyrus, left fusiform gyrus, left middle occipital gyrus, and left middle occipital gyrus. Between the left superior occipital gyrus, the right superior margin gyrus, the left auxiliary motor area and the bilateral Rolandic operculum. Bilateral middle frontal gyrus and medial right superior frontal gyrus in right superior margin gyrus [P0.05, multiple comparison (AlphaSim) combined with cluster 89 ontogenin] .DIPG group (behavioral suppression group and no behavioral inhibition reduction group), right superior frontal gyrus medial, right superior frontal gyrus, right superior frontal gyrus. There was no significant correlation between the ReHo value of the left fusiform gyrus and the CBCL scale score (P0.05), but there was a positive correlation between the ReHo value of the right superior gyrus and the CBCL scale score (r = 0.950 P0. 001, r = 0. 709 / P = 0. 033). Conclusion the abnormal function of brain area associated with inhibition and control may be due to the "low energy" and "low efficiency" of the related brain area in the children with reduced behavior inhibition of DIPG. This study provides a new idea for the study of brain stem lesions in brain function.
【作者单位】：首都医科大学附属北京天坛医院放射科;北京市神经外科研究所;
【基金】：国家自然科学基金国际(地区)合作交流项目(81361120402) 国家自然青年科学基金(81301193) 北京市医院管理局临床医学发展专项经费资助(XMLX201508)
【分类号】：R445.2;R739.41

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