软骨延迟增强磁共振成像对基质诱导的自体软骨细胞移植术后移植软骨的纵向评估

发布时间：2018-08-09 07:39

【摘要】：目的利用软骨延迟增强磁共振成像(dGEMRIC)技术评估基质诱导的自体软骨细胞移植(MACI)术后移植软骨的GAG分层分布特点。方法 7例MACI术后患者(14处软骨缺损)在术后3、6、12个月进行dGEMRIC检查,测量正常软骨和移植软骨的全层和深浅层△R1值。各时间点正常软骨和移植软骨△R1值的比较采用配对t检验。各时间点间移植软骨的△R1值变化采用单因素方差分析。结果 MACI术后各时间点正常软骨全层△R1值均小于移植软骨△R1值(P均0.05)。MACI术后各时间点移植软骨深层△R1值小于浅层△R1值,差异具有统计学意义(P均0.05)。MACI术后3个月与6个月移植软骨△R1值的比较不具有统计学意义(P均0.05),而术后6个月移植软骨△R1值明显大于12个月移植软骨△R1值,且差异具有统计学意义(P均0.05)。结论 dGEMRIC技术可作为无创性评估移植软骨的修复过程的有效手段。
[Abstract]:Objective to evaluate the GAG stratification distribution of cartilage grafts after (MACI) transplantation with matrix induced autologous chondrocytes by using delayed enhanced magnetic resonance imaging (dGEMRIC). Methods dGEMRIC was performed in 7 patients (14 cartilage defects) after MACI at 3 and 12 months after operation. The R1 values in the whole and deep layers of normal cartilage and grafted cartilage were measured. T-test was used to compare the R1 values of normal cartilage and transplanted cartilage at each time point. Single factor analysis of variance (ANOVA) was used for the change of R1 value of transplanted cartilage at different time points. Results the R1 value of normal cartilage at all time points after MACI was lower than that of grafted cartilage R1 (P0. 05). The R1 value of deep layer of transplanted cartilage was lower than that of superficial R1 at different time points after Maci. The difference was statistically significant (P 0.05). There was no significant difference in R1 value between 3 months and 6 months after MACI (P 0.05), but the R1 value of transplanted cartilage at 6 months after operation was significantly higher than that at 12 months. The difference was statistically significant (P 0.05). Conclusion dGEMRIC technique can be used as a non-invasive method to evaluate the repair process of cartilage grafts.
【作者单位】：中国人民解放军总医院南楼放射科;西门子(中国)有限公司医疗业务领域磁共振事业部;
【分类号】：R684;R445.2

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