原发性三叉神经痛患者基于ALFF的静息态功能MRI成像研究

发布时间：2018-08-09 18:23

【摘要】：目的采用基于低频振荡振幅(ALFF)的功能磁共振成像技术观察原发性三叉神经痛(PTN)静息状态下的脑活动特点。方法采用3.0 T MRI对29例PTN患者和26名年龄、性别相匹配的健康志愿者进行静息态功能磁共振数据采集。利用DPARSF软件对图像预处理并计算两组受试者全脑ALFF值,采用SPM 8软件对数据行两样本t检验,最终获得PTN患者ALFF值有统计学意义的脑区;并将PTN患者振幅增高脑区的ALFF值与病程做相关分析。结果与正常对照组相比(校正后,P0.05水平),PTN患者在静息状态下双侧丘脑、中央后回、岛叶、杏仁核及小脑等脑区ALFF值均增高;双侧前扣带回、后扣带回、角回、楔前叶等脑默认模式网络脑区ALFF值减低;未发现PTN患者ALFF值增高脑区的ALFF值与病程有相关性。结论 PTN患者双侧丘脑、中央后回、岛叶、杏仁核及小脑等脑区ALFF值增高,提示这些脑区可能与三叉神经痛的发生发展有关;PTN患者ALFF值增高脑区的ALFF值均与病程无显著相关性。
[Abstract]:Objective To observe the characteristics of brain activity under resting state of primary trigeminal neuralgia (PTN) by functional magnetic resonance imaging (fMRI) based on low frequency oscillation amplitude (ALFF). Methods 3 T MRI were used to collect the resting state power magnetic resonance data of 29 PTN patients and 26 age and sex matched healthy volunteers. The DPARSF software was used to analyze the images. The total brain ALFF value of two groups of subjects was pretreated and calculated. The SPM 8 software was used to test the two samples of the data line with t test, and the ALFF value of PTN patients was statistically significant, and the ALFF value of the PTN patients with higher amplitude in the brain region was correlated with the course of disease. The results were compared with the normal control group (corrected, P0.05 level), and the PTN patients were in the resting state. The ALFF value of bilateral thalamus, central posterior gyrus, island leaf, amygdala and cerebellum increased, and the ALFF value of brain area in the brain area of bilateral anterior cingulate gyrus, posterior cingulate gyrus, angular gyrus, and the anterior wedge of the brain decreased, and the ALFF value of PTN patients with higher ALFF was not correlated with the course of disease. Conclusion PTN patients were bilateral thalamus, central posterior gyrus, insula, amygdaloid nucleus and The higher ALFF value in the cerebellar brain region suggests that these brain regions may be related to the development of trigeminal neuralgia, and there is no significant correlation between the ALFF value of the brain region and the ALFF value of the patients with PTN.
【作者单位】：潍坊医学院附属益都中心医院CT/MRI室;徐州医学院附属医院医学影像科;徐州医学院附属医院神经外科;
【分类号】：R745.11;R445.2

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