声辐射力脉冲弹性成像结合HMGB1在宫颈癌分期中的初步应用
发布时间：2018-08-17 14:08
【摘要】：目的探讨声脉冲辐射力弹性成像(ARFI)技术结合高迁移率族蛋白1(HMGB1)在宫颈癌分期中的应用价值。方法应用ARFI技术测量42例宫颈癌患者(宫颈癌组)、55例宫颈上皮内瘤样病变(CIN组)及40例健康体检者(对照组)宫颈声触诊组织量化值(VTQ)。三组均采用酶联免疫分析法(ELISA)检测血清HMGB1浓度,采用电化学发光免疫法检测血清CA125、CEA水平。分析宫颈癌组VTQ值、血清HMGB1水平与CA125、CEA之间的相关性。结果宫颈癌组VTQ值(2.43±0.87)m/s大于CIN组(1.61±0.73)m/s和对照组(1.55±0.45)m/s;差异有显著统计学意义(P0.01)。宫颈癌组HMGB1(9.42±3.51)ng/ml大于CIN组(3.25±2.89)ng/ml和对照组(3.13±1.53)ng/ml,差异有统计学意义(P0.01)。宫颈癌组I、Ⅱ、Ⅲ+Ⅳ期VTQ值、血清HMGB1水平随分期增加而增大,差异有统计学意义(P0.05);CIN组与对照组比较,VTQ值及血清HMGB1水平差异无统计学意义(P0.05)。宫颈癌组VTQ、血清HMGB1水平与CA125、CEA呈正相关(P0.01)。结论声辐射力脉冲弹性成像技术结合血清HMGB1水平有助于宫颈癌范围及分期的评估。
[Abstract]:Objective to evaluate the value of (ARFI) combined with high mobility group protein 1 (HMGB1) in the staging of cervical cancer. Methods ARFI technique was used to measure the quantitative value of cervical acoustic palpation tissue in 42 patients with cervical cancer (cervical cancer group) and 55 patients with cervical intraepithelial neoplasia (CIN group) and 40 healthy controls (control group). Serum HMGB1 concentration was detected by enzyme linked immunosorbent assay (ELISA) and electrochemiluminescence immunoassay (ECLIA). To analyze the correlation between VTQ value, serum HMGB1 level and CA125 CEA in cervical cancer group. Results the VTQ of cervical cancer group (2.43 卤0.87) m / s was significantly higher than that of CIN group (1.61 卤0.73) m / s and control group (1.55 卤0.45) m / s (P0.01). HMGB1 in cervical cancer group (9.42 卤3.51) ng/ml was significantly higher than that in CIN group (3.25 卤2.89) ng/ml and control group (3.13 卤1.53) ng / ml (P0.01). The level of VTQ and serum HMGB1 increased with the increase of stage I, 鈪，
本文编号：2187879
[Abstract]:Objective to evaluate the value of (ARFI) combined with high mobility group protein 1 (HMGB1) in the staging of cervical cancer. Methods ARFI technique was used to measure the quantitative value of cervical acoustic palpation tissue in 42 patients with cervical cancer (cervical cancer group) and 55 patients with cervical intraepithelial neoplasia (CIN group) and 40 healthy controls (control group). Serum HMGB1 concentration was detected by enzyme linked immunosorbent assay (ELISA) and electrochemiluminescence immunoassay (ECLIA). To analyze the correlation between VTQ value, serum HMGB1 level and CA125 CEA in cervical cancer group. Results the VTQ of cervical cancer group (2.43 卤0.87) m / s was significantly higher than that of CIN group (1.61 卤0.73) m / s and control group (1.55 卤0.45) m / s (P0.01). HMGB1 in cervical cancer group (9.42 卤3.51) ng/ml was significantly higher than that in CIN group (3.25 卤2.89) ng/ml and control group (3.13 卤1.53) ng / ml (P0.01). The level of VTQ and serum HMGB1 increased with the increase of stage I, 鈪，
本文编号：2187879
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