莫迪司、马根维显在乳腺动态增强MR扫描中的应用价值研究-Meta分析

发布时间：2018-08-17 13:18

【摘要】：目的采用Meta分析方法综合评价莫迪司和马根维显在乳腺MRI筛查中的诊断价值,旨在为对比剂选择提供更加确信的依据。方法检索2013年1月前所有已经发表的中英文文献,主要来源于the Cochrane Library,PUBMED,EMBASE,中国生物医学文献数据库,中国科技期刊全文数据库等。根据纳入和排除标准,全面检索关于莫迪司、马根维显在乳腺动态增强MR扫描中的相关英文和中文文献。纳入文献质量评价采用QUADAS,数据分析采用Meta-Disc 1.4软件。结果按照纳入和排除标准共纳入文献17篇,涉及1934例患者。莫迪司和马根维显的总敏感性分别为0.924(0.902,0.943)和0.838(0.817,0.858)。两种对比剂合并的特异度为0.974(0.969,0.979)和0.935(0.927,0.942),用卡方检验比较P值;与此同时,汇总受试者工作特征曲线(SROC)的曲线下面积(AUC)分别为0.9781和0.9215,用Z检验比较P值。结论与马根维显相比,莫迪司具有更敏感的诊断性能以及更有效的对比效应。鉴于其许多固有的缺陷以及纳入研究方法的局限性,因此,迫切需要更高质量的研究,以进一步确认莫迪司的诊断价值。
[Abstract]:Objective to evaluate the diagnostic value of motifs and Margenvir in breast MRI screening by Meta analysis, in order to provide a more reliable basis for the selection of contrast agents. Methods all the published literatures in Chinese and English before January 2013 were searched, mainly from the Cochrane Library PUBMEDUMASE, Chinese Biomedical Literature Database, full text Database of Chinese Science and Technology Journals, etc. According to the criteria of inclusion and exclusion, the relevant English and Chinese literatures on motifs and Magan Weixian in dynamic enhanced Mr scanning of mammary glands were searched. QUADASA was used to evaluate the literature quality and Meta-Disc 1.4 software was used to analyze the data. Results according to the criteria of inclusion and exclusion, 17 articles were included, involving 1934 patients. The total sensitivities of motifs and Mackenvir were 0.924 (0.9020.9043) and 0.838 (0.817 ~ 0.858), respectively. The combined specificity of the two contrasts were 0.974 (0.9690.9979) and 0.935 (0.9270.9942), P values were compared by chi-square test, at the same time, the area under the curve area (AUC) of (SROC) was 0.9781 and 0.9215respectively, and P value was compared by Z test. Conclusion Modix has more sensitive diagnostic performance and more effective contrast effect than Margenvir. In view of its many inherent defects and the limitations of incorporating research methods, higher quality research is urgently needed to further confirm the diagnostic value of motifs.
【作者单位】：兰州军区兰州总医院影像诊断科;
【基金】：甘肃省自然科学基金资助项目(编号:145RJZA145)
【分类号】：R445.2;R655.8

【共引文献】